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Immunological features of a lung cancer patient achieving an objective response with anti-programmed death-1 blockade

Toshiko Kamata1,2, Shigetoshi Yoshida1, Mariko Takami2

  • 1Department of Thoracic Surgery, School of Medicine, International University of Health and Welfare, Atami Hospital, Atami, Japan.

Cancer Science
|November 3, 2019
PubMed

Insights

Immune checkpoint inhibitors combined with surgery show promise for metastatic lung cancer. Post-treatment analysis revealed key immune responses, including germinal center formation and T-cell activity.

Area of Science:

  • Oncology
  • Immunology
  • Surgical Oncology

Background:

  • Immune checkpoint inhibitors (ICIs) are established treatments for metastatic lung cancer.
  • Pre-treatment tumor microenvironment profiles in responders are increasingly understood.
  • The role of salvage surgery and post-treatment immune profiles in responding patients remain understudied.
Keywords:
anti-PD-1 antibodyimmunotherapylung cancersurgerytumor-infiltrating lymphocyte

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