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Leukemic relapse presenting as sciatic nerve involvement by chloroma (granulocytic sarcoma).
M J Stillman1, W Christensen, R Payne
1Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021.
Cancer
|November 1, 1988
Summary
A child
Area of Science:
- Pediatric Oncology
- Neurology
- Hematology
Background:
- Acute nonlymphocytic leukemia (ANLL) relapse can manifest with diverse symptoms.
- Neurologic complications, though rare, require thorough investigation.
Observation:
- A pediatric patient with ANLL relapse presented with subacute sciatic nerve mononeuropathy.
- Surgical exploration revealed a chloroma (granulocytic sarcoma) within the distal sciatic nerve.
Findings:
- Despite surgical resection and irradiation, the patient did not regain nerve function.
- Symptomatic neuropathic pain persisted post-treatment.
- This case is potentially the sole reported instance of peripheral nervous system chloroma without concurrent central nervous system leukemia.
Implications:
- Highlights the importance of considering rare neurologic presentations in leukemic relapse.
- Underscores the potential for peripheral nervous system involvement by chloromas.
- Suggests limitations of current treatment modalities for chloroma-induced peripheral neuropathy.