Related Experiment Video
Updated: Jan 4, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
Alternatives to Transfusion
Sara Emily Bachert1, Prerna Dogra2, Leonard I Boral1
1Department of Pathology and Laboratory Medicine, University of of Kentucky Medical Center, Lexington.
Objectives:
We discuss two main categories of blood substitutes: perfluorocarbons and hemoglobin-based oxygen carriers.
Methods:
We provide a review of the notable products developed in both categories and include their attributes as well as their setbacks.
Results:
We contribute a case report tothe growing literature of the successful use of Sanguinate.
Conclusions:
We find that artificial oxygen carriers are an attractive field of research because of the practical limitations and the multitude of potential complications that surround human blood transfusions.
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