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Ganglionic stimulants activate NM nicotinic receptors in autonomic ganglia, falling into two categories: nicotine mimetics [e.g., lobeline, dimethylpiperazine, tetramethylammonium] and muscarinic receptor agonists [e.g., muscarine, methacholine]. The first category's action is rapid and blocked by nicotinic receptor antagonists, while the second category's action is delayed and blocked by atropine-like agents. Nicotine, an alkaloid, affects the heart rate by stimulating...
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Related Experiment Video

Updated: Jan 4, 2026

Spectral Confocal Imaging of Fluorescently tagged Nicotinic Receptors in Knock-in Mice with Chronic Nicotine Administration
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Nicotine Use Disorders in Adolescents.

Dana A Cavallo1, Suchitra Krishnan-Sarin1

  • 1Yale School of Medicine, SAC, 34 Park Street, New Haven, CT 06519, USA.

Pediatric Clinics of North America
|November 5, 2019
PubMed
Summary

Nicotine use disorder remains a significant concern for adolescents, despite declining rates of traditional tobacco products. Emerging trends like e-cigarette use highlight the need for effective interventions to protect this vulnerable population.

Keywords:
AdolescentNicotineTobaccoTobacco treatment

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Area of Science:

  • Adolescent Health
  • Addiction Medicine
  • Public Health

Background:

  • Adolescent nicotine use disorder persists despite decreasing traditional tobacco product use.
  • The rise of electronic cigarettes presents new challenges and concerns for youth.
  • Understanding current trends is crucial for effective public health strategies.

Purpose of the Study:

  • To review current understanding of adolescent nicotine addiction and its measurement.
  • To examine potential health risks and associated conditions (comorbidities) in adolescent nicotine users.
  • To explore existing and novel interventions for reducing adolescent tobacco and nicotine use.

Main Methods:

  • Literature review of studies on adolescent nicotine use, addiction, and interventions.
  • Analysis of trends in tobacco and electronic cigarette product usage among adolescents.
  • Synthesis of data on health risks, comorbidities, and intervention effectiveness.

Main Results:

  • Nicotine addiction remains prevalent in adolescents, with evolving product use patterns.
  • Electronic cigarettes represent a significant and alarming trend in adolescent nicotine consumption.
  • A range of psychosocial and pharmacological interventions exist, with novel approaches showing promise.

Conclusions:

  • Adolescent nicotine use disorder requires ongoing attention and tailored interventions.
  • Addressing new trends like e-cigarette use is critical for adolescent public health.
  • Further research into novel interventions is needed to effectively combat adolescent tobacco use.