Cystic fibrosis bone disease: Pathophysiology, assessment and prognostic implications
Abeer Anabtawi1, Trang Le2, Melissa Putman3
1Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Kansas Medical Center, Kansas City, KS, USA.
Summary
Cystic fibrosis bone disease (CFBD) is a common complication of cystic fibrosis (CF). This review discusses current evidence on CFBD diagnosis and monitoring, highlighting the need for better understanding and management strategies.
Area of Science:
- Bone Metabolism and Disease
- Pulmonary Medicine
- Pediatric Endocrinology
Background:
- Cystic fibrosis bone disease (CFBD) is a frequent complication in cystic fibrosis (CF) patients.
- CFBD contributes to fractures, morbidity, and mortality.
- The underlying pathophysiology of CFBD is complex and not fully understood.
Purpose of the Study:
- To review and discuss the current evidence regarding diagnostic tools for CFBD.
- To evaluate methods for monitoring CFBD progression and treatment efficacy.
- To highlight knowledge gaps in CFBD management.
Main Methods:
- Systematic literature review of studies on CFBD.
- Analysis of diagnostic and monitoring tools for CFBD.
- Synthesis of current evidence on CFBD pathophysiology.
Main Results:
- Limited studies exist on validated diagnostic and monitoring tools for CFBD.
- Current evidence suggests a multifactorial etiology for CFBD.
- Therapeutic decisions and monitoring strategies for CFBD require further investigation.
Conclusions:
- There is a critical need for improved diagnostic and monitoring tools for CFBD.
- Further research into CFBD pathophysiology is essential for effective management.
- Enhanced understanding and management of CFBD are crucial for improving patient outcomes.
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