Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

673
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
673
Cystic Fibrosis: Management01:24

Cystic Fibrosis: Management

422
Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
Sinus disease and chronic...
422
Adrenal Gland Disorders01:27

Adrenal Gland Disorders

2.8K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
2.8K
Hormones of the Adrenal Glands01:31

Hormones of the Adrenal Glands

4.4K
Adrenal hormones play a pivotal role in maintaining the body's electrolyte balance and orchestrating responses to stress, showcasing the intricate functions of the adrenal cortex and medulla.
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...
4.4K
Anatomy of the Adrenal Glands01:17

Anatomy of the Adrenal Glands

4.1K
The adrenal or supra-renal glands, situated above the kidneys and aligned with the twelfth rib, are paired pyramid-shaped structures crucial for the body's stress response. During stress, these glands secrete hormones vital for adaptive physiological reactions.
These glands possess a distinctive yellow tinge due to the stored cholesterol and fatty acids required for hormone synthesis. They are encased in a fibrous capsule and cushioned by fat.
The adrenal gland comprises two distinct...
4.1K
Hypothalamic-Pituitary Axis01:37

Hypothalamic-Pituitary Axis

65.2K
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
65.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reversible Mitochondrial Iron Toxicity in Wolfram Syndrome Type 2 Monogenic Diabetes.

The Journal of clinical endocrinology and metabolism·2026
Same author

Multi-omics identification of amino acid and redox dysregulation in cystic fibrosis-related diabetes.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society·2026
Same author

Clinical Presentation and Outcomes of Insulinomas in Pediatric Patients.

Hormone research in paediatrics·2026
Same author

Geometry of the proximal femur during growth and its contribution to childhood fractures in healthy children.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026
Same author

Machine learning analysis of continuous glucose monitoring identifies a novel dysglycemic phenotype found in most people with cystic fibrosis.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society·2026
Same author

Insulin Hypersecretion and Increased Ectopic Fat in South Asian American Adolescents and Young Adults Compared With White and African American Peers: The CHARISMA Study.

Diabetes care·2026

Related Experiment Video

Updated: Jan 4, 2026

Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis
05:56

Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis

Published on: August 29, 2025

402

Adrenal function in cystic fibrosis.

Maria Socorro Rayas1, Andrea Kelly2, Kara S Hughan3

  • 1Division of Pediatric Endocrinology and Diabetes, University of Texas Health San Antonio, 7703 Floyd Curl, San Antonio, TX 78229, USA.

Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society
|November 5, 2019
PubMed
Summary

Cystic fibrosis therapies, particularly corticosteroids, can disrupt the hypothalamic-pituitary-adrenal axis, leading to adrenal insufficiency. Guidelines are provided for managing this condition in CF patients.

Keywords:
ACTH stimulation testCorticosteroidsCortisolCystic fibrosisIatrogenic Cushing syndromeIatrogenic adrenal insufficiency

More Related Videos

Forskolin-induced Swelling in Intestinal Organoids: An In Vitro Assay for Assessing Drug Response in Cystic Fibrosis Patients
07:04

Forskolin-induced Swelling in Intestinal Organoids: An In Vitro Assay for Assessing Drug Response in Cystic Fibrosis Patients

Published on: February 11, 2017

19.9K
Generation of Human Nasal Epithelial Cell Spheroids for Individualized Cystic Fibrosis Transmembrane Conductance Regulator Study
08:00

Generation of Human Nasal Epithelial Cell Spheroids for Individualized Cystic Fibrosis Transmembrane Conductance Regulator Study

Published on: April 11, 2018

11.0K

Related Experiment Videos

Last Updated: Jan 4, 2026

Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis
05:56

Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis

Published on: August 29, 2025

402
Forskolin-induced Swelling in Intestinal Organoids: An In Vitro Assay for Assessing Drug Response in Cystic Fibrosis Patients
07:04

Forskolin-induced Swelling in Intestinal Organoids: An In Vitro Assay for Assessing Drug Response in Cystic Fibrosis Patients

Published on: February 11, 2017

19.9K
Generation of Human Nasal Epithelial Cell Spheroids for Individualized Cystic Fibrosis Transmembrane Conductance Regulator Study
08:00

Generation of Human Nasal Epithelial Cell Spheroids for Individualized Cystic Fibrosis Transmembrane Conductance Regulator Study

Published on: April 11, 2018

11.0K

Area of Science:

  • Endocrinology
  • Pulmonology
  • Pharmacology

Background:

  • Cystic fibrosis (CF) itself doesn't target the adrenal gland.
  • Common CF treatments, like corticosteroids, significantly impact the hypothalamic-pituitary-adrenal (HPA) axis.
  • These therapies can lead to iatrogenic Cushing syndrome and adrenal insufficiency.

Purpose of the Study:

  • To provide practical guidelines for screening, diagnosing, and treating iatrogenic adrenal insufficiency in CF patients.
  • To highlight the effects of corticosteroid therapy on the HPA axis in CF.
  • To identify research gaps concerning CF therapies and adrenal function.

Main Methods:

  • Review of existing literature, primarily from asthma research.
  • Synthesis of guidelines for managing corticosteroid-induced adrenal dysfunction.
  • Identification of the need for CF-specific studies.

Main Results:

  • Corticosteroid use in CF can cause iatrogenic Cushing syndrome and adrenal insufficiency.
  • Prolonged use suppresses endogenous cortisol production.
  • Negative impacts on bone health, growth, and glucose metabolism are noted.

Conclusions:

  • Iatrogenic adrenal insufficiency is a significant concern in CF patients using corticosteroids.
  • Current management guidelines are largely based on asthma literature.
  • Further research is crucial to understand the specific impact of CF therapies on adrenal function and other endocrinopathies in CF.