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The 3D Genome as a Target for Anticancer Therapy
Omar L Kantidze1, Katerina V Gurova2, Vasily M Studitsky3
1Laboratory of Genome Stability, Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.
Abstract:
The role of 3D genome organization in the precise regulation of gene expression is well established. Accordingly, the mechanistic connections between 3D genome alterations and disease development are becoming increasingly apparent. This opinion article provides a snapshot of our current understanding of the 3D genome alterations associated with cancers. We discuss potential connections of the 3D genome and cancer transcriptional addiction phenomenon as well as molecular mechanisms of action of 3D genome-disrupting drugs. Finally, we highlight issues and perspectives raised by the discovery of the first pharmaceutical strongly affecting 3D genome organization.
Insights
3D genome organization impacts gene expression and disease. This review explores 3D genome changes in cancer, linking them to transcriptional addiction and drug mechanisms.
Area of Science:
- Genomics
- Molecular Biology
- Cancer Research
Background:
- The three-dimensional (3D) genome organization is crucial for regulating gene expression.
- Alterations in 3D genome structure are increasingly linked to disease development.
- Understanding these connections is vital for advancing medical science.
Purpose of the Study:
- To provide an overview of current knowledge regarding 3D genome alterations in cancers.
- To explore the relationship between 3D genome organization and cancer's transcriptional addiction.
- To discuss the mechanisms of drugs that disrupt 3D genome organization.
Main Methods:
- This is an opinion article, synthesizing existing research and expert perspectives.
- Literature review and analysis of current findings on 3D genome organization in cancer.
- Discussion of emerging concepts and future directions.
Main Results:
- 3D genome alterations are associated with various cancers.
- The 3D genome plays a role in the phenomenon of cancer's transcriptional addiction.
- Drugs targeting 3D genome organization show potential therapeutic avenues.
Conclusions:
- The study of 3D genome organization offers new insights into cancer biology.
- Targeting 3D genome structure represents a promising area for cancer drug development.
- Further research is needed to fully elucidate the implications of pharmaceutical interventions affecting 3D genome organization.
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