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Torsten Grothe1, Franziska Wandrey1, Cornelia Schuerch1

  • 1Mibelle Group Biochemistry, Mibelle AG, Bolimattstrasse 1, 5033, Buchs, AG, Switzerland.

Phytotherapy Research : PTR
|November 5, 2019
PubMed
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Pea sprout extract shows promise for hair growth. Oral or topical application can enhance hair density and reduce hair loss by stimulating key hair growth genes.

Area of Science:

  • Dermatology
  • Trichology
  • Nutraceuticals

Background:

  • Hair loss is a widespread concern with limited effective treatments.
  • Current options often have side effects or insufficient efficacy.
  • Pea sprout extract's topical benefits are known, but oral effectiveness is unexplored.

Purpose of the Study:

  • To investigate the molecular mechanism of pea sprout extract on hair growth genes.
  • To evaluate the efficacy of oral pea sprout extract supplementation for reducing hair loss.

Main Methods:

  • Topical application of 2% pea sprout extract fluid on scalp zones in 10 volunteers.
  • Gene expression analysis for fibroblast growth factor-7 (FGF7) and noggin.
  • Pilot study involving daily oral intake of 100 mg pea sprout extract (AnaGain™ Nu) for 8 weeks in 21 volunteers.
Keywords:
FGF7hair growthhair lossnogginpea sprout extract

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Main Results:

  • Topical application significantly enhanced FGF7 (56%) and noggin (85%) gene expression.
  • Oral pea sprout extract intake reduced hair loss within 28 days.
  • No adverse events were reported during the oral supplementation study.

Conclusions:

  • Pea sprout extract demonstrates a dual action for promoting hair growth.
  • Topical application influences key hair growth genes.
  • Oral supplementation offers a safe and effective method to reduce hair shedding.