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Strain-dependent differences in murine susceptibility to coccidia.

P H Klesius, S E Hinds

    Infection and Immunity
    |December 1, 1979
    PubMed
    Summary

    Mouse strain differences reveal that resistance to Eimeria ferrisi infection is primarily thymus-dependent and genetically controlled. Cell-mediated immunity is crucial for this resistance, though host genetics can modify its effectiveness.

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    Area of Science:

    • Immunology
    • Genetics
    • Parasitology

    Background:

    • Eimeria ferrisi infection susceptibility varies significantly among different mouse strains.
    • Understanding the genetic and immunological basis of this variation is key to controlling coccidial infections.

    Purpose of the Study:

    • To investigate the genetic control and immunological mechanisms underlying differential susceptibility of mouse strains to Eimeria ferrisi.
    • To determine the role of thymus-dependent cell-mediated immunity in resistance to Eimeria ferrisi.

    Main Methods:

    • Infection of eight mouse strains with six infectious doses of Eimeria ferrisi, monitoring mortality for 12 days.
    • Genetic crosses (F(1) hybrids) between susceptible and resistant strains to assess dominance of resistance.
    • Infection of athymic (nu/nu) and heterozygous (nu/+) mice on a resistant BALB/c background to evaluate thymus dependence.
    • Pharmacological impairment of cell-mediated immunity in resistant AKR mice using antithymus serum.

    Main Results:

    • C57BL/6 and HA/ICR mice were susceptible; A/He, AKR, BALB/c, CBA, C3H/Anf, and DBA/2 mice were resistant.
    • Resistance to Eimeria ferrisi infection was found to be a dominant genetic trait.
    • Resistance was demonstrated to be thymus-dependent, as athymic mice showed reduced resistance.
    • Impairment of cell-mediated immunity in resistant AKR mice led to partial susceptibility, while susceptible strains maintained some cell-mediated reactivity.

    Conclusions:

    • Cell-mediated immunity is essential for host resistance against Eimeria ferrisi infection.
    • Genetic factors significantly influence the host's immune response and susceptibility to coccidiosis.
    • Further research into immune response genes controlling coccidial immunity is warranted.

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