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Updated: Jan 4, 2026

Performing and Processing FNA of Anterior Fat Pad for Amyloid
Published on: October 30, 2010
Hemodialysis-associated soft tissue amyloidomas of the chest and abdominal wall
Junaid Nasir1, Paul J Der Mesropian1, Llewellyn Foulke2
1Department of Medicine, Division of Nephrology, Albany Medical Center, Albany, New York, USA.
Abstract:
Amyloidoma is a highly unusual presentation of amyloidosis in tumoral or nodular form. Isolated soft tissue amyloidomas in individuals with end-stage renal disease on chronic hemodialysis is exceedingly rare, particularly in the era of advanced dialysis technologies. We report the case of a 55-year-old male with end-stage renal disease due to autosomal-dominant polycystic kidney disease, on HD for over 30 years, who was found to have soft-tissue, dialysis-related (β2 -microglobulin) amyloidomas (DRA). He presented with painful, palpable masses within the thoracic and abdominal walls. Serum β2 -microglobulin level was only mildly elevated at 24.9 mg/L. Biopsy confirmed amyloidosis with positivity for Congo Red staining and apple-green birefringence under polarized light. Amyloid subtyping with immunohistochemistry showed positive β2 -microglobulin staining within the deposits. Conservative therapy involving pain management and close monitoring resulted in eventual improvement in symptoms and thus proved to be a viable option for treatment.
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