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Rapid Mix Preparation of Bioinspired Nanoscale Hydroxyapatite for Biomedical Applications

Rapid Mix Preparation of Bioinspired Nanoscale Hydroxyapatite for Biomedical Applications

Published on: February 23, 2017

Synthetic hydroxyapatite: a recruiting platform for biologically active molecules.

Deepak Bushan Raina¹, Yang Liu¹, Hanna Isaksson^1,2

¹Faculty of Medicine, Department of Clinical Sciences, Orthopedics, Lund University, Lund.

Acta Orthopaedica

|November 5, 2019

Summary

Locally implanted synthetic hydroxyapatite (HA) particles effectively recruit systemically administered drugs like zoledronic acid, enhancing local drug concentrations and reducing side effects. This novel targeted drug delivery method biologically activates the HA material.

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Area of Science:

Biomaterials Science
Drug Delivery Systems
Nanotechnology

Background:

Targeted drug delivery is crucial for maximizing therapeutic efficacy and minimizing systemic toxicity.
Hydroxyapatite (HA) is a biocompatible material with potential for drug sequestration.

Purpose of the Study:

To investigate if locally implanted synthetic hydroxyapatite (HA) particles can serve as a drug-recruiting moiety for systemically administered drugs.
To evaluate the targeted drug accretion and local biological effects of HA particles.

Main Methods:

Synthetic HA particles were implanted in rat muscle pouches.
Binding of systemically administered zoledronic acid (ZA), tetracycline, and 18F-fluoride to HA was studied.
Local biological effects were assessed in an implant integration model with systemic ZA administration.

Main Results:

Systemically administered drugs (ZA, tetracycline, 18F) showed significant accretion to HA particles in the muscle pouch.
Implants containing HA particles demonstrated increased peri-implant bone volume and peak force.
HA particles showed capacity for reloading with ZA, with microparticles and nanoparticles accumulating 73% and 77% more 14C-ZA respectively upon re-administration.

Conclusions:

Locally implanted HA particles facilitate targeted delivery and accretion of systemically administered drugs.
This approach enhances local drug concentrations and shows potential for biologically activating implanted materials.
HA particles offer a promising platform for novel targeted drug delivery strategies.