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Parkinson's Disease: Treatment

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...

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Updated: Jan 4, 2026

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Published on: July 16, 2014

Square Biphasic Pulse Deep Brain Stimulation for Parkinson's Disease: The BiP-PD Study.

Sol De Jesus^1,2, Michael S Okun¹, Kelly D Foote³

¹Department of Neurology, Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, FL, United States.

Frontiers in Human Neuroscience

|November 5, 2019

Summary

Square biphasic pulse shaping (sqBIP) deep brain stimulation (DBS) is safe and well-tolerated for Parkinson's disease (PD). This novel approach offers similar benefits to conventional DBS for movement disorders.

Keywords:

Parkinson’s disease biphasic pulse stimulation deep brain stimulation neuromodulation pulse shape therapy

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Author Spotlight: Automated Deep Brain Stimulation for Parkinson's Disease - Exploring the Possibilities and Challenges of Home Monitoring

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Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

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Published on: July 16, 2014

A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test

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Published on: July 14, 2023

Area of Science:

Neurology
Biomedical Engineering
Neurosurgery

Background:

Conventional deep brain stimulation (DBS) for Parkinson's disease (PD) uses pulses with active and passive phases.
Eliminating the passive phase via pulse-shaping may offer advantages for treating movement disorders.

Purpose of the Study:

To assess the safety and tolerability of square biphasic pulse shaping (sqBIP) DBS in Parkinson's disease patients.
To compare sqBIP DBS with conventional DBS in a small pilot study.

Main Methods:

A pilot study involving nine participants compared sqBIP DBS to conventional DBS.
Safety and tolerability were evaluated over a 3-hour period post-stimulation.
Friedman's test analyzed blinded assessments at various time points.

Main Results:

Square biphasic pulses were found to be safe and well-tolerated by all participants.
sqBIP DBS demonstrated comparable motor performance to conventional DBS.
No significant differences were observed in accelerometer or gait measures between the two methods.

Conclusions:

Square biphasic pulses are a safe and well-tolerated alternative to conventional DBS for Parkinson's disease.
sqBIP DBS provides comparable benefits to conventional DBS.
Further research is warranted to explore the effectiveness of sqBIP in specific Parkinson's disease patient populations.