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Ifosfamide plasma clearance in relation to polymorphic debrisoquine oxidation
P A Philip1, L D Lewis, C A James
1Department of Clinical Pharmacology, United Medical School, Guy's Hospital, London Bridge, U.K.
Cancer Chemotherapy and Pharmacology
|January 1, 1988
Abstract:
Ifosfamide (IF) pharmacokinetics and the plasma (NBP)-alkylating activity were determined in 33 patients with different tumours after the administration of IF as single-agent chemotherapy. All subjects had been phenotyped for debrisoquine oxidation. There is a lack of correlation between the debrisoquine metabolic ratio (DMR) and either the total plasma clearance of IF (CLIF) or the AUC of the plasma NBP-alkylating activity.