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Related Experiment Video

Updated: Jan 4, 2026

A Murine Model of Cervical Spinal Cord Injury to Study Post-lesional Respiratory Neuroplasticity

A Murine Model of Cervical Spinal Cord Injury to Study Post-lesional Respiratory Neuroplasticity

Published on: May 28, 2014

Reversible bilateral phrenic nerve paralysis.

Neil Maharaj¹, Donald W Cockcroft¹

¹Division of Respirology, Critical Care & Sleep Medicine, Department of Medicine, University of Saskatchewan, Royal University Hospital, 103 Hospital Drive, Saskatoon, Saskatchewan, S7N 0W8, Canada.

Respiratory Medicine Case Reports

|November 5, 2019

Summary

This summary is machine-generated.

Bilateral phrenic nerve paralysis, a rare condition, can cause severe breathing issues. This case study shows a patient who recovered fully with ventilatory support, suggesting neuralgic amyotrophy as a likely cause.

Keywords:

Diaphragmatic paralysis Neuralgic amyotrophy Phrenic nerve paralysis Supine hypoxemia

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Retrograde Neuroanatomical Tracing of Phrenic Motor Neurons in Mice

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Published on: February 22, 2018

Area of Science:

Neurology
Pulmonology

Background:

Bilateral phrenic nerve paralysis is a rare, life-threatening condition often caused by trauma or neurological disorders.
It can lead to severe respiratory distress, particularly when lying down.

Observation:

A patient presented with rapid-onset bilateral phrenic nerve paralysis, experiencing severe positional dyspnea and oxygen desaturation when supine.
Initial nerve conduction studies suggested amyotrophic lateral sclerosis (ALS).

Findings:

The patient received nocturnal ventilatory support using bilevel positive airway pressure (BiPAP).
Over four years, the patient experienced a near-complete recovery of phrenic nerve function.
The clinical presentation and recovery pattern retrospectively indicated neuralgic amyotrophy as the most probable diagnosis.

Implications:

This case highlights the importance of considering neuralgic amyotrophy in cases of apparent bilateral phrenic nerve paralysis.
Prompt supportive care, including ventilatory assistance, can lead to significant recovery.
Early diagnosis and management are crucial for improving outcomes in patients with this rare condition.