Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Random exercise stress test in diagnosing effort angina.

A Suyama¹, K Sunagawa, K Hayashida

¹Information Science Laboratory for Biomedicine, Kyushu University Medical School, Fukuoka, Japan.

|October 1, 1988

Summary

This study introduces a novel ST impulse response method for diagnosing effort angina without strenuous exercise. Patients with effort angina showed significantly prolonged ST depression compared to healthy individuals.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Corrigendum to "Intrathecal non-viral interleukin-10 gene therapy ameliorates neuropathic pain as measured by both classical static allodynia and a novel supra-spinally mediated pain assay, the Two-Arm Rodent Somatosensory (TARS) task" [Brain Behav. Immun. 111 (2023) 177-185].

Brain, behavior, and immunity·2024

Same author

Intrathecal non-viral interleukin-10 gene therapy ameliorates neuropathic pain as measured by both classical static allodynia and a novel supra-spinally mediated pain assay, the Two-Arm Rodent Somatosensory (TARS) task.

Brain, behavior, and immunity·2023

Same author

Transcatheter aortic valve implantation: current status and future perspectives.

European heart journal·2018

Same author

A method of gentle hydration to prepare oil-free giant unilamellar vesicles that can confine enzymatic reactions.

Biochemistry and biophysics reports·2017

Same author

Venous superdrained gastric tube pull-up procedure for hypopharyngeal and cervical esophageal reconstruction reduces postoperative anastomotic leakage and stricture.

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus·2017

Same author

Spinal antinociceptive effects of the novel NOP receptor agonist PWT2-nociceptin/orphanin FQ in mice and monkeys.

British journal of pharmacology·2015

Area of Science:

Cardiology
Medical Diagnostics
Physiology

Background:

Exercise stress testing is crucial for diagnosing effort angina but carries risks.
Minimizing complications while improving diagnostic accuracy is a key challenge.

Purpose of the Study:

To evaluate a new method, the ST impulse response, for diagnosing effort angina.
To assess if this method can improve diagnostic performance and reduce risks compared to traditional stress tests.

Main Methods:

Developed an 'ST impulse response' by analyzing ST changes during intermittent, random-sequence treadmill walking.
Utilized Fourier transform to analyze beat-to-beat ST level changes and exercise sequences.
Calculated the transfer function and converted it to the time domain to derive the ST impulse response.

Related Experiment Videos

Main Results:

The ST impulse response showed an initial depression followed by restoration (Type I response) in 89% of subjects.
Healthy volunteers had an average ST depression duration of 8 ± 3 seconds.
Patients with effort angina exhibited significantly prolonged ST depression (23 ± 14 seconds, p < 0.05).
Patients with atypical chest pain showed no significant difference from healthy volunteers.

Conclusions:

The ST impulse response is a promising, non-strenuous method for diagnosing effort angina.
Prolonged ST depression duration in the ST impulse response effectively differentiates effort angina patients.
This technique offers a safer alternative for diagnosing effort angina, particularly in at-risk individuals.