Biomarkers to predict the response to cardiac resynchronization therapy
Ward Heggermont1,2, Angelo Auricchio3,4, Marc Vanderheyden1
1Cardiovascular Research Centre, OLV Hospital Aalst, Moorselbaan 164, B, Aalst, Belgium.
Summary
Predicting patient response to cardiac resynchronization therapy (CRT) is crucial. Current biomarker research is fragmented, hindering accurate patient selection for CRT and requiring standardized endpoints for better prediction.
Area of Science:
- Cardiology
- Biomarker Research
Background:
- Cardiac resynchronization therapy (CRT) is a key treatment for heart failure patients with wide QRS duration.
- A significant portion of patients do not respond to CRT, necessitating improved patient selection methods.
Purpose of the Study:
- To critically appraise the available literature on biomarkers for predicting CRT response.
- To identify challenges and propose improvements for future biomarker research in CRT.
Main Methods:
- A comprehensive review of existing studies on biomarkers and CRT response was conducted.
- The review focused on critically evaluating the data and identifying trends in biomarker research.
Main Results:
- Biomarker research in CRT patients is highly fragmented and lacks uniformity.
- The use of non-uniform endpoints to define CRT response limits data comparison and hinders progress.
Conclusions:
- Standardizing the definition of CRT response and relevant endpoints is essential for advancing predictive research.
- Improved uniformity in research will facilitate better patient selection and optimize CRT outcomes.
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