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Related Experiment Videos

Rate and delta checks compared for selected chemistry tests.

D A Lacher1, D P Connelly

  • 1Department of Pathology, Medical College of Ohio, Toledo 43699.

Clinical Chemistry
|October 1, 1988
PubMed
Summary

Comparing delta and rate checks for chemistry tests revealed significant differences. Rate checks showed large dispersion, influenced by testing protocols, impacting clinical chemistry quality control.

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Area of Science:

  • Clinical Chemistry
  • Laboratory Medicine
  • Quality Control

Background:

  • Delta checks are common for monitoring laboratory test result consistency.
  • Rate checks, incorporating time intervals, offer a potentially more sensitive quality control method.
  • Evaluating these methods is crucial for accurate clinical diagnostics.

Purpose of the Study:

  • To compare the performance of delta check and rate check methods.
  • To assess the impact of data transformation on check method effectiveness.
  • To analyze the influence of inter-specimen time intervals on rate checks.

Main Methods:

  • Compared delta and rate check methods for 12 clinical chemistry tests.
  • Calculated rate checks by dividing delta checks by inter-specimen interval time.
  • Utilized untransformed and absolute value-transformed data for analysis.

Main Results:

  • Delta check distributions were asymmetrical for several analytes (e.g., calcium, phosphorus).
  • Asymmetry led to varied check limits between transformed and untransformed data.
  • Rate checks exhibited substantial dispersion, with multimodal inter-specimen times.

Conclusions:

  • The choice of data transformation impacts delta check limit setting.
  • Rate checks present challenges due to large dispersion and variable time intervals.
  • Standardized testing protocols influence inter-specimen time, affecting rate check reliability.

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