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Updated: Jan 4, 2026

Light-driven Enzymatic Decarboxylation
Published on: May 22, 2016
Decarbonylative Phosphorylation of Carboxylic Acids via Redox-Neutral Palladium Catalysis
Chengwei Liu1, Chong-Lei Ji2, Tongliang Zhou1
1Department of Chemistry , Rutgers University , 73 Warren Street , Newark , New Jersey 07102 , United States.
Abstract:
We describe the direct synthesis of organophosphorus compounds from ubiquitous aryl and vinyl carboxylic acids via decarbonylative palladium catalysis. The catalytic system shows excellent scope and tolerates a wide range of functional groups (>50 examples). The utility of this powerful methodology is highlighted in the late-stage derivatization directly exploiting the presence of the prevalent carboxylic acid functional group. DFT studies provided insight into the origin of high bond activation selectivity and P(O)-H isomerization pathway.
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