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SERS Substrate with Silk Nanoribbons as Interlayer Template.

Fengrui Xu1, Fengguo Ma2, Zhaozhao Ding1,3

  • 1National Engineering Laboratory for Modern Silk and Collaborative Innovation Center of Suzhou Nano Science and Technology , Soochow University , 215123 Suzhou , People's Republic of China.

ACS Applied Materials & Interfaces
|November 5, 2019
PubMed
Summary

Researchers created novel silk nanoribbon and gold nanoparticle structures to enhance surface-enhanced Raman scattering (SERS) detection. This advancement offers highly sensitive and uniform SERS signals for potential biomedical imaging applications.

Keywords:
SERSgoldhot spotsnanoribbonssandwich structure

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Spectroscopy

Background:

  • Surface-enhanced Raman scattering (SERS) performance is significantly improved by creating localized electromagnetic field enhancements known as hot spots.
  • Silk nanoribbons (SNRs) and gold nanoparticles (AuNPs) are promising nanomaterials for SERS applications due to their unique properties.

Purpose of the Study:

  • To develop and optimize sandwich hot spot structures using SNRs and AuNPs for enhanced SERS detection.
  • To evaluate the sensitivity, uniformity, and biocompatibility of the fabricated SERS substrates for potential biomedical applications.

Main Methods:

  • Assembly of silk nanoribbons (SNRs) and gold nanoparticles (AuNPs) via electrostatic interactions to form sandwich hot spot structures.
  • Optimization of SNR and AuNP ratios to maximize SERS signal intensity and uniformity.
  • Assessment of SERS sensitivity, enhancement factor (EF), and relative standard deviation (RSD).
  • Evaluation of cytocompatibility and in vitro bioimaging capacity of the SERS substrates.

Main Results:

  • Achieved high SERS sensitivity down to 10-13 M with an enhancement factor (EF) of 5.8 × 106.
  • Demonstrated improved SERS spectrum uniformity with a relative standard deviation (RSD) of approximately 11.2%.
  • Confirmed the biocompatibility of SNRs and the effectiveness of the SERS substrates in vitro bioimaging.

Conclusions:

  • The developed sandwich hot spot structures using silk nanoribbons and gold nanoparticles significantly enhance SERS performance.
  • The fabricated SERS substrates exhibit excellent sensitivity, uniformity, and biocompatibility, making them suitable for advanced biomedical applications.
  • This study highlights the potential of naturally derived materials and tailored nanostructures for creating high-performance bioimaging systems.