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Plasma fructosamine assay in children with insulin-dependent diabetes mellitus
1Department of Laboratory Medicine, Osaka City University Medical School, Japan.
Insights
Plasma fructosamine effectively monitors glycemic control in children with insulin-dependent diabetes mellitus (IDDM). This practical measurement, unaffected by HbF, correlates well with HbAI and HbAIc levels.
Area of Science:
- Pediatric Endocrinology
- Clinical Chemistry
Background:
- Plasma fructosamine reflects average blood glucose levels over 2-3 weeks.
- Glycemic control assessment in children with diabetes is crucial for long-term health.
- Age-related variations in fructosamine levels in non-diabetic children require consideration.
Purpose of the Study:
- To evaluate plasma fructosamine as a marker for glycemic control in children with insulin-dependent diabetes mellitus (IDDM).
- To compare fructosamine levels in diabetic children with age-matched controls.
- To assess the correlation between plasma fructosamine and established glycemic markers (HbAI, HbAIc) in pediatric patients.
Main Methods:
- Plasma fructosamine concentrations were measured in non-diabetic children and children with IDDM.
- Fructosamine levels were compared between different age groups of non-diabetic children and with healthy adults.
- Correlations between plasma fructosamine and HbAI/HbAIc were analyzed in children with IDDM.
Main Results:
- Non-diabetic children under 4 years had lower plasma fructosamine than older children.
- Plasma fructosamine levels in children with IDDM were double those of age-matched controls.
- High correlations were observed between fructosamine and HbAI (r=0.799) and HbAIc (r=0.841) in children with IDDM.
Conclusions:
- Plasma fructosamine is a practical and useful indicator of glycemic control in children with IDDM.
- The small sample volume and lack of HbF interference make fructosamine measurement advantageous in pediatric diabetes management.
- Fructosamine measurements provide a reliable assessment of glycemic status in pediatric patients with diabetes mellitus.
Abstract:
Plasma concentrations of fructosamine, an indicator of glycated plasma proteins, were measured in non-diabetic children and children with insulin-dependent diabetes mellitus (IDDM) to see if they also correlate with glycemic control in children as well as in adults. Non-diabetic children aged less than 4 yr had significantly lower plasma fructosamine than non-diabetic children aged 4 or more. Total plasma protein in these children was slightly lower or close to that of older children. There was no difference in fructosamine between non-diabetic children aged 4 or more and healthy adult subjects. Plasma fructosamine in children with IDDM was twofold that of age-matched controls. In children with IDDM, correlations between fructosamine and HbAI (r = 0.799) or HbAIc (r = 0.841) were high. The measurement of plasma fructosamine, which is practical in children because of the small sample volume needed and no influence of HbF, is useful in the management of children with IDDM.