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Published on: January 31, 2020
Invariant NKT Cells and Rheumatic Disease: Focus on Primary Sjogren Syndrome
Chiara Rizzo1, Lidia La Barbera2, Marianna Lo Pizzo3
1Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, Rheumatology Section-University of Palermo, Piazza delle Cliniche, 2, 90110 Palermo, Italy. chiararizzo87@gmail.com.
Abstract:
Primary Sjogren syndrome (pSS) is a complex autoimmune disease mainly affecting salivary and lacrimal glands. Several factors contribute to pSS pathogenesis; in particular, innate immunity seems to play a key role in disease etiology. Invariant natural killer (NK) T cells (iNKT) are a T-cell subset able to recognize glycolipid antigens. Their function remains unclear, but studies have pointed out their ability to modulate the immune system through the promotion of specific cytokine milieu. In this review, we discussed the possible role of iNKT in pSS development, as well as their implications as future markers of disease activity.
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