Age-related changes in the immune system of mice of eight medium and long-lived strains and hybrids. I. Organ,...

Fifty-three organ, cellular and activity indices were assessed in aging mice of 8 strains and hybrids (5 inbred strains, 1 random bred strain and 2 hybrids of inbred strains) in an attempt to determine which aspects of immunologic aging are characteristic of the species. The results indicate that thymic weight, cellular, and activity indices exhibit a statistically significant negative correlation with age for mice of all 8 strains and hybrids; and B cell cellular indices show a statistically significant positive correlation with age for all mice, while the B cell activity index, lipopolysaccharide response, is dependent on the strain or hybrid. This correlation study supports the view that the T cell component of the immune system deteriorates with age while the B cell component remains relatively intact. Further, the results suggest that thymic aging is a characteristic of the mouse species and that the intrinsic "clock" for immunologic aging resides in the thymus, because most splenic and lymph node T cell activity and cellular indices are associated with thymic weight and cellular indices. Finally, the findings that indices which correlate best with age show the same trend for all strains and hybrids examined suggest that (a) if randomly occurring somatic mutation does play a role in immunologic aging, its influence is limited, and (b) genetic factors not easily influenced by environmental factors regulate immunologic aging.