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Co-occurrence of human papillomavirus (HPV) in newborns and their parents

Mariusz Skoczyński1, Anna Goździcka-Józefiak2, Anna Kwaśniewska3

  • 1Department of Obstetrics and Pathology of Pregnancy, Medical University of Lublin, Lublin, Poland. mskoczynski@wp.pl.

BMC Infectious Diseases
|November 6, 2019
PubMed

Insights

Human papillomavirus (HPV) 16/18 infections are transmitted periconceptionally, with infected parents posing a significant risk to newborns. This study highlights the father's role in HPV transmission chains and potential childhood disease risks.

Area of Science:

  • Virology
  • Epidemiology
  • Public Health

Background:

  • Human papillomavirus (HPV) transmission routes, including in utero and vertical, are established, but the father's role in the epidemic chain is less understood.
  • Perinatal HPV infections may lead to childhood diseases and increase the risk of cervical cancer in female offspring.
  • Investigating HPV co-occurrence in parents and offspring is crucial for implementing effective preventive strategies.

Purpose of the Study:

  • To determine the incidence of common HPV 16/18 infections in newborns and their parents.
  • To assess the role of periconceptional transmission in acquired HPV infections in newborns.

Main Methods:

  • A study involving 146 pregnant women, their partners, and newborns.
  • Testing for HPV 16/18 DNA using polymerase chain reaction (PCR) with type-specific primers.
  • Analyzing the relationship between neonatal and parental HPV infection using multivariable regression.

Main Results:

  • HPV DNA was detected in 13.01% of newborns, 19.18% of mothers, and 13.7% of fathers.
  • Newborns delivered by HPV-positive mothers had a significantly increased risk of infection (OR=26.08).
  • Newborns with HPV-positive fathers (OR=22.13) or both infected parents (OR=24.20) also showed a substantially higher risk of acquiring HPV.

Conclusions:

  • Periconceptional transmission plays a significant role in acquired HPV 16/18 infections in newborns.
  • Infected parents, including fathers, are a considerable source of HPV infection for their offspring.
  • Findings underscore the importance of parental HPV status in understanding neonatal infection risks.
Abstract

Keywords:
Maternal infectionPaternal infectionPericonceptional infectionPerinatal transmission

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