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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

890
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
890
Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

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Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
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Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

820
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
820
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

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Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
432
Vaccinations01:51

Vaccinations

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Overview
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Related Experiment Video

Updated: Jan 4, 2026

Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice
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Vaccination in the Elderly and IBD.

Anthony J Choi1, Preston Atteberry1, Dana J Lukin2,3

  • 1Division of Gastroenterology and Hepatology, New York Presbyterian Hospital-Weill Cornell Medical College, New York, USA.

Current Treatment Options in Gastroenterology
|November 6, 2019
PubMed
Summary

This review highlights vaccination knowledge gaps in inflammatory bowel disease (IBD) care, especially for elderly patients. It offers updated best practices for integrating new vaccines and therapies in IBD management.

Keywords:
Crohn’s diseaseElderlyInflammatory bowel diseasePreventive health maintenanceUlcerative colitisVaccination

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Area of Science:

  • Gastroenterology
  • Immunology
  • Public Health

Background:

  • Significant gaps in vaccination knowledge and utilization exist among healthcare providers for patients with inflammatory bowel disease (IBD).
  • Recent advancements in IBD therapeutics, including novel immunosuppressive agents, necessitate updated vaccination strategies.
  • The elderly IBD population presents unique challenges and considerations for vaccine efficacy and safety.

Purpose of the Study:

  • To update healthcare practitioners on best practices for vaccinating patients with IBD.
  • To provide a framework for integrating optimal vaccination strategies, considering new vaccines and evolving IBD treatments.
  • To specifically address vaccination needs within the elderly IBD population.

Main Methods:

  • Literature review of current vaccination guidelines and IBD treatment protocols.
  • Analysis of the impact of different immunosuppressive therapies on vaccine response.
  • Synthesis of evidence regarding new vaccine availability and recommendations for IBD patients.

Main Results:

  • Immunosuppressive therapies in IBD have differential implications for vaccination strategies.
  • New vaccines, such as the recombinant zoster vaccine, are now available and recommended for the IBD population.
  • A clear understanding of vaccination best practices is essential for IBD providers to optimize patient care.

Conclusions:

  • Optimizing vaccination strategies is crucial for preventing infections in IBD patients, particularly the elderly.
  • Providers need updated knowledge to navigate complex vaccination decisions influenced by IBD therapies.
  • Implementing a structured approach to vaccination can improve outcomes for adult and elderly IBD patients.