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Updated: Jan 4, 2026

Pathological Analysis of Lung Metastasis Following Lateral Tail-Vein Injection of Tumor Cells
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Trace Elements in the Lung Tissue Affected by Sarcoidosis.

Olga Denisova1, George Chernogoryuk2, Natalya Baranovskaya3

  • 1Hospital Therapy Department, Siberian State Medical University, Moskovsky Trakt 2, Tomsk, 634050, Russia. oadeni@yandex.ru.

Biological Trace Element Research
|November 6, 2019
PubMed
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Distribution Patterns and Accumulation Factors of Rare Earth Elements in the Organism of Manchurian Wapiti and Wild Boar in Primorsky Krai, Russian Far East.

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[The role of occupational factors in the development and course of respiratory sarcoidosis].

Terapevticheskii arkhiv·2022

This study found higher levels of certain heavy metals and rare earth elements in the lungs of sarcoidosis patients. These findings suggest environmental exposure may trigger granulomatous inflammation in sarcoidosis.

Area of Science:

  • Environmental Science
  • Toxicology
  • Pulmonary Medicine

Background:

  • Sarcoidosis is an inflammatory disease characterized by granuloma formation.
  • The exact cause of sarcoidosis remains unknown, but environmental factors are suspected.
  • Elemental composition of lung tissue in sarcoidosis patients has not been extensively studied.

Purpose of the Study:

  • To investigate the elemental composition of lung tissue in patients with sarcoidosis.
  • To explore potential correlations between elemental levels and sarcoidosis.
  • To test the hypothesis that environmental heavy metals and rare earth elements contribute to sarcoidosis.

Main Methods:

  • Neutron activation analysis was used to identify 28 chemical elements in lung tissue samples from 76 sarcoidosis patients and control subjects.
Keywords:
EnvironmentLungsSarcoidosisTrace elements

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  • Spearman correlation analysis was employed to examine associations between elemental levels.

    • Main Results:

    • Significantly elevated levels of calcium (Ca), iron (Fe), chromium (Cr), cobalt (Co), cesium (Cs), europium (Eu), lutetium (Lu), thorium (Th), hafnium (Hf), gold (Au), and uranium (U) were found in sarcoidosis lungs compared to controls.
    • No significant differences in zinc (Zn), rubidium (Rb), and several other elements were observed.
    • Strong positive correlations were identified between several elements, including Fe-Cr, Eu-La, and Hf-Cr.

    Conclusions:

    • The findings support the hypothesis that sarcoidosis may result from an immune response to environmental heavy metals and rare earth elements.
    • Elevated calcium and iron levels might play a role in granuloma formation and separation from surrounding tissues.
    • Further research is warranted to elucidate the role of specific elements in sarcoidosis pathogenesis.