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Six-Step Total Synthesis of (±)-Conolidine
Guoqing Chen1, Chen Wang1, Liangbang Zou1
1Zhejiang Key Laboratory of Alternative Technologies for Fine Chemicals Process , Shaoxing University , Shaoxing , 312000 , People's Republic of China.
Abstract:
A concise total synthesis of (±)-conolidine, a potent nonopioid analgesic, in 19% overall yield is described here. A gold(I)-catalyzed Conia-ene reaction (Toste cyclization) and a Pictet-Spengler reaction served as key transformations for assembling the 1-azabicyclo[4.2.2]decane core and defining the geometry of the exocyclic double bond. The activation energies of formation of the vinyl-gold intermediates were calculated and revealed a silyl enol ether with an unprotected indole moiety as a suitable precursor for the Toste cyclization. This six-step synthesis did not involve any nonstrategic redox manipulations.
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