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MicroRNA-195 as a prognostic factor for cancer survival outcome in China: a meta-analysis

Ni Wang1, Yang Cao2, Xianxiu Ge1

  • 1Medical Center for Digestive Diseases, Second Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, People's Republic of China.

Cancer Management and Research
|November 6, 2019
PubMed
Abstract

Insights

High microRNA-195 expression indicates a favorable prognosis in various cancers. This meta-analysis confirms its potential as a prognostic biomarker for improved patient outcomes.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biomarker Research

Background:

  • MicroRNA-195 (miR-195) is frequently dysregulated in cancers and impacts tumorigenesis.
  • Its role as a prognostic biomarker is suggested but requires validation due to inconsistent findings.

Purpose of the Study:

  • To validate the prognostic value of microRNA-195 in human tumors through a comprehensive meta-analysis.
  • To clarify the association between miR-195 expression levels and cancer patient prognosis.

Main Methods:

  • A systematic literature search was performed on PubMed up to December 31, 2018.
  • Publication quality was assessed using PRISMA statement guidelines.
  • Pooled hazard ratios (HR) and odds ratios (OR) with 95% confidence intervals (CI) were calculated.

Main Results:

  • The meta-analysis included 12 studies with 940 cancer patients.
  • High miR-195 expression correlated with favorable tumor-node-metastasis (pooled OR=0.16), reduced lymph node metastasis (pooled OR=0.25), and less distant metastasis (pooled OR=0.26).
  • Elevated miR-195 levels were significantly associated with better overall survival (pooled HR=0.46).

Conclusions:

  • Elevated microRNA-195 expression serves as a potential predictive biomarker for favorable prognosis across various cancer types.
  • miR-195's role in cancer progression and survival warrants further investigation.
Keywords:
biomarkerexpressionmeta-analysismicroRNA-195prognosis

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