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Nontoxic concentration of amphotericin B for intravitreal use--evaluated by in vitro ERG
K Kawasaki1, J Ohnogi, Y Okayama
1Department of Ophthalmology Kanazawa University School of Medicine, Japan.
Abstract:
Amphotericin B (AMPH)-induced changes of the electroretinogram (ERG) were studied in the in vitro eye-cup of the albino rabbit. The a-wave, b-wave, oscillatory potentials and c-wave were not changed by 1 microM AMPH, and these all were slightly suppressed by 5 microM AMPH. These changes were mostly reversible. The b-wave and oscillatory potentials were greatly suppressed by 50 microM AMPH. These changes were only partially reversible 75 minutes after re-perfusion without AMPH.