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A Case of Histiocytic Sarcoma Arising from Mycosis Fungoides
Ethan A Burns1, Cesar Gentille2, Saro Kasparian1
1Houston Methodist Hospital, Department of Medicine, 6550 Fannin St, Ste 1101, Houston, TX 77030, USA.
Abstract:
Histiocytic sarcoma (HS) is an uncommon malignant neoplasm arising from mature histiocytes and most commonly characterized by the immunophenotypic expression of CD68, CD163, or lysozyme. Although rare, HS arising as a second primary malignancy following hematolymphoid neoplasms has been reported. To our knowledge, this is the first reported case of HS occurring as a second primary malignancy in a patient with mycosis fungoides (MF), with the retained immunophenotype markers CD30 and CD4.
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