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Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
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Lymphatic-type "Angiosarcoma" With Prominent Lymphocytic Infiltrate
Anthony P Martinez1,2, Mauricio Zapata3, Paula E North4
1Departments of Pathology and Laboratory Medicine.
The American Journal of Surgical Pathology
|November 6, 2019
Summary
We identified a unique vascular tumor, lymphatic-type angiosarcoma, with distinct features. This tumor type shows a more favorable prognosis compared to other cutaneous angiosarcomas.
Area of Science:
- Vascular Tumors
- Dermatopathology
- Surgical Pathology
Background:
- Angiosarcomas are rare, aggressive vascular tumors.
- Cutaneous angiosarcomas often present with a poor prognosis.
- Distinct subtypes of angiosarcoma require further characterization.
Purpose of the Study:
- To describe the clinicopathologic, immunohistochemical, and follow-up data of a unique vascular tumor.
- To propose the designation of "lymphatic-type angiosarcoma" for this entity.
- To compare its natural history to other cutaneous angiosarcomas.
Main Methods:
- Retrospective review of 21 cases of a unique vascular tumor.
- Histopathological evaluation including nuclear grade and architectural patterns.
- Immunohistochemical staining for lymphatic markers (podoplanin, Prox-1, LYVE-1).
- Analysis of clinical follow-up data.
Main Results:
- The tumor exhibited angiosarcoma characteristics with lymphatic differentiation and a prominent lymphocytic infiltrate.
- Cases were classified as low-grade (n=10) or high-grade (n=11).
- All cases expressed lymphatic markers; podoplanin and Prox-1 were frequently positive.
- Follow-up in 17 patients revealed a more favorable outcome than typical cutaneous angiosarcomas, with local recurrence in 9 and metastasis in 2 cases.
Conclusions:
- Lymphatic-type angiosarcoma is a distinct vascular neoplasm with specific histopathological and immunohistochemical features.
- This entity appears to have a more favorable clinical course than other angiosarcomas.
- Further research is warranted to elucidate the molecular underpinnings and optimize management strategies.
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