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Joshua Petimar1,2, Sheryl L Rifas-Shiman2, Marie-France Hivert2,3

  • 1Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

Pediatric Obesity
|November 6, 2019
PubMed
Summary

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Mid-childhood hair cortisol concentration (HCC) showed no link to adolescent obesity or most cardiometabolic markers. A small increase in HOMA-IR was the only exception, with no changes observed in HCC over time.

Area of Science:

  • Endocrinology
  • Pediatric Health
  • Metabolic Health

Background:

  • Elevated cortisol levels in children are linked to stress and potential health issues.
  • Understanding the long-term impact of hair cortisol concentration (HCC) on adolescent metabolic health is crucial.

Purpose of the Study:

  • To investigate the association between mid-childhood hair cortisol concentration (HCC) and changes in HCC (ΔHCC) with early adolescent adiposity and cardiometabolic biomarkers.
  • To assess the relationship between stress markers in childhood and metabolic health outcomes in adolescence.

Main Methods:

  • Utilized data from Project Viva, a pre-birth cohort study.
  • Measured HCC in 599 children in mid-childhood and 426 in early adolescence.
  • Employed multivariable linear regression to analyze associations with various adiposity and cardiometabolic measures.
Keywords:
adipositychildrencohort studieshair cortisol concentrationmetabolic syndrome

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Main Results:

  • No significant associations were found between mid-childhood HCC and adolescent BMI-for-age-and-sex z score, waist circumference, waist-height ratio, or metabolic risk z score.
  • A slight increase in log-transformed HOMA-IR was observed with higher mid-childhood HCC.
  • No associations were detected between change in HCC (ΔHCC) and any of the measured outcome variables.

Conclusions:

  • Mid-childhood hair cortisol concentration (HCC) is not significantly associated with early adolescent adiposity or most cardiometabolic biomarkers.
  • A minor increase in HOMA-IR was the only significant finding, suggesting limited long-term impact of childhood cortisol levels on metabolic health markers.
  • Changes in HCC from mid-childhood to early adolescence did not correlate with adolescent adiposity or cardiometabolic health.