Related Experiment Video

Updated: Jan 4, 2026

Tear-Derived Exosomal miR-15a as New Diagnostic Tool for Diabetic Retinopathy
07:45

Tear-Derived Exosomal miR-15a as New Diagnostic Tool for Diabetic Retinopathy

Published on: December 30, 2025

54

Association between polymorphisms in microRNAs and susceptibility to diabetes mellitus: A meta-analysis

Xi Chen1, Wenjing Wang2, Ruien Li1

  • 1Endocrine Metabolic Disease Section.

Medicine
|November 7, 2019
PubMed
Abstract

Insights

Single-nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) may influence diabetes mellitus (DM) risk. Specifically, miR-146a, miR-27a, and miR-124 polymorphisms show potential associations with DM susceptibility, varying by ethnicity.

Area of Science:

  • Genetics
  • Molecular Biology
  • Epidemiology

Background:

  • Growing evidence links microRNA (miRNA) single-nucleotide polymorphisms (SNPs) to diabetes mellitus (DM) susceptibility.
  • Previous findings are often contradictory, necessitating a comprehensive analysis.

Purpose of the Study:

  • To conduct a meta-analysis to clarify the association between miRNA SNPs and DM risk.
  • To determine the definitive contribution of miRNA genetic variations to diabetes development.

Main Methods:

  • Systematic literature search of PubMed and Cochrane Library databases.
  • Meta-analysis of six studies (2773 cases, 2632 controls) using STATA software.
  • Evaluation of associations under five genetic models, calculating odds ratios (ORs) and 95% confidence intervals (95% CIs).

Main Results:

  • miR-146a (rs2910164) G allele/GG genotype associated with increased DM risk in Latin Americans.
  • miR-27a (rs895819) CC genotype linked to decreased DM risk in Asians.
  • miR-124 (rs531564) CC genotype showed reduced DM probability across ethnicities; no associations found for miR-375, miR-128a, miR-194a.

Conclusions:

  • miR-146a, miR-27a, and miR-124 polymorphisms represent potential ethnicity-dependent or -independent risk factors for DM.
  • Further research is warranted to elucidate the precise mechanisms and ethnic variations in miRNA SNP-associated DM risk.

More Related Videos

Generation of High Quality Chromatin Immunoprecipitation DNA Template for High-throughput Sequencing ChIP-seq09:52

Generation of High Quality Chromatin Immunoprecipitation DNA Template for High-throughput Sequencing ChIP-seq

Published on: April 19, 2013

24.8K
Quantitative Real-Time Polymerase Chain Reaction Evaluation of MicroRNA Expression in Kidney and Serum of Mice with Age-Dependent Renal Impairment06:48

Quantitative Real-Time Polymerase Chain Reaction Evaluation of MicroRNA Expression in Kidney and Serum of Mice with Age-Dependent Renal Impairment

Published on: April 29, 2022

2.6K

Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
15.2K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.7K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
23.8K
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
17.8K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.0K