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Primary mediastinal ependymoma: A case report and literature review
Wei-Biao Ye1, Jian-Ping Zhou1, Yong-Qiang Xu1
1Department of Thoracic Surgery and Pathology, Dongguan People's Hospital of Southern Medical University.
Rationale:
Ependymomas are neuroepithelial tumors that typically occur in the central nervous system. Ependymomas arising in the mediastinum are exceedingly rare, with only approximately 9 isolated cases reported in the literature to date.
Patient Concerns:
A 35-year-old woman was referred to our hospital with complaints of progressive back pain for 3 months. Physical examination revealed decreased breathing sounds and tenderness. Contrast-enhanced computed tomography showed a soft tissue mass with heterogeneous enhancement in the right posterior mediastinum.
Diagnoses:
The diagnosis of primary mediastinal ependymomas (PMEs) was confirmed by postoperative histopathologic examination.
Interventions And Outcomes:
The patient underwent surgical resection of the tumor and experienced local recurrence with neck metastasis 2 years postoperatively. She underwent reoperation for the recurrent tumors and received postoperative radiotherapy and adjuvant chemotherapy. Two years later, the patient is doing well, with no evidence of tumor progression or recurrence.
Lessons:
Since PMEs are exceedingly rare, treatment options are limited. Surgical resection seems to be the mainstay of treatment. Further evidence-based studies are required to prove the benefit of radiotherapy and chemotherapy in the treatment of PMEs.
