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Updated: Jan 4, 2026
08:46
A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
Published on: August 12, 2020
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Differences between congenital-syphilis presenting as sepsis and neonatal sepsis: A case-control study
Yang Liu1,2, Yu Zhu1,2, Yibin Wang1,2
1Department of Pediatrics, West China Second Hospital, Sichuan University.
Medicine
|November 7, 2019
Summary
Congenital syphilis (CS) presenting as sepsis is a critical condition often missed. Early diagnosis and treatment are crucial for better infant outcomes, as untreated CS leads to severe complications and higher mortality.
Area of Science:
- Neonatal Medicine
- Pediatric Infectious Diseases
- Syphilology
Background:
- Congenital syphilis (CS) poses significant risks to newborns.
- CS presenting as sepsis is a severe, often initially unrecognized, clinical challenge.
- Prompt diagnosis and intervention are vital for improving infant prognosis.
Purpose of the Study:
- To evaluate the benefits of early and accurate diagnosis for infants with congenital syphilis presenting as sepsis.
- To compare clinical characteristics and outcomes of CS sepsis versus typical neonatal sepsis.
Main Methods:
- Retrospective study of infants diagnosed with congenital syphilis sepsis (2011-2018).
- Comparison with a control group of neonates with culture-positive sepsis.
- Analysis of clinical signs, laboratory findings, and patient outcomes.
Main Results:
- Congenital syphilis sepsis group had a higher mortality rate and progression to multiple organ dysfunction syndrome (MODS).
- Significant differences observed in clinical manifestations (rash, desquamation, organomegaly) and laboratory markers (Hb, PLT, WBC, CRP, ALT, AST) between groups.
- Younger age and impaired liver function were associated with worse outcomes in CS patients.
Conclusions:
- Pediatricians must enhance awareness of congenital syphilis as a cause of neonatal sepsis.
- Improved diagnostic strategies and timely syphilis screening for pregnant women are essential to reduce infant morbidity and mortality.
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