Rodent gene drives for conservation: opportunities and data needs.

Area of Science:

• Ecology
• Genetics
• Conservation Biology

Background:

• Invasive rodents pose significant threats to global biodiversity, human health, and food security, especially on islands.
• Current rodent control methods face limitations, necessitating innovative solutions.
• Islands are critical biodiversity hotspots and vulnerable to invasive species impacts.

Purpose of the Study:

• To review current knowledge on natural and synthetic gene drive systems in mice (Mus musculus).
• To identify key knowledge gaps in gene drive technology for invasive rodent control.
• To explore multidisciplinary findings relevant to these gaps and discuss engagement strategies.

Main Methods:

• Literature review of natural and synthetic gene drive systems in mice.
• Analysis of findings from various scientific disciplines relevant to gene drive knowledge gaps.
• Consideration of regulatory, stakeholder, and community engagement approaches.

Main Results:

• Mice (Mus musculus) serve as a key model for developing gene drive systems.
• Gene drives show potential for reducing rodent reproduction and enabling island eradication.
• Multidisciplinary research is essential for assessing gene drive potential.

Conclusions:

• Gene drive technologies present a significant opportunity for biodiversity conservation, human health, and food security.
• Addressing knowledge gaps through multidisciplinary research is vital for responsible gene drive development.
• Transparent and inclusive engagement with regulatory bodies, stakeholders, and communities is necessary.