Related Experiment Video
Updated: Jan 4, 2026
08:18
Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
Published on: July 27, 2022
1.4K
Parenteral systems for statin delivery: a review
Shahla Korani1, Samira Bahrami2, Mitra Korani3
1Research center of oils and fats, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Lipids in Health and Disease
|November 7, 2019
Summary
Oral statin drugs face bioavailability challenges due to metabolism. This review explores diverse non-oral delivery methods to enhance statin drug efficacy and therapeutic outcomes.
Area of Science:
- Pharmacology
- Drug Delivery Systems
Background:
- Oral drug administration is preferred for statins due to convenience and cost.
- Oral statin administration suffers from low bioavailability caused by hepatic first-pass metabolism and gastrointestinal degradation.
Purpose of the Study:
- To review diverse non-oral delivery methods for statin administration.
- To highlight alternative routes that can improve statin bioavailability and therapeutic efficacy.
Main Methods:
- Literature review of non-oral statin delivery systems.
- Analysis of various alternative administration routes and their impact on drug bioavailability.
Main Results:
- Non-oral delivery systems offer potential solutions to overcome oral administration limitations.
- Alternative routes can significantly enhance the bioavailability and therapeutic effectiveness of statin drugs.
Conclusions:
- Exploring non-oral routes is crucial for optimizing statin therapy.
- Advanced drug delivery systems can improve patient outcomes by enhancing statin efficacy.
More Related Videos
Related Concept Videos
01:25Routes of Drug Administration: Parenteral
2.7K
The administration of drugs via parenteral routes allows for direct drug introduction into the systemic circulation, resulting in high bioavailability because the medication bypasses the harsh conditions of the gastrointestinal tract and hepatic metabolism.
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
2.7K
01:29Drug Delivery: Parenteral Route
1.4K
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
1.4K
01:16Drug Delivery: Overview
685
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
685
01:20Lipid-Lowering Drugs: Statins and Miscellaneous Agents
1.3K
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
1.3K
01:18Drug Delivery: Enteral Route
1.5K
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
1.5K
01:18Routes of Drug Administration: Enteral
6.1K
Medications can be administered through the enteral route using liquids, capsules, or tablets.
Enteral administration involves drug administration via the mouth in two ways: orally or sublingually.
Unlike sublingually drugs, drugs that are taken orally pass through the gastrointestinal (GI) tract and get metabolized by the liver. Once metabolized, the drug is absorbed into the systemic circulation, reaching different body parts via the bloodstream. However, while passing through the stomach,...
Enteral administration involves drug administration via the mouth in two ways: orally or sublingually.
Unlike sublingually drugs, drugs that are taken orally pass through the gastrointestinal (GI) tract and get metabolized by the liver. Once metabolized, the drug is absorbed into the systemic circulation, reaching different body parts via the bloodstream. However, while passing through the stomach,...
6.1K