Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hypersensitivities01:30

Hypersensitivities

6.8K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
6.8K
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

2.4K
The pathophysiology of pneumonia involves the following steps:
2.4K
Pneumonia I: Introduction01:30

Pneumonia I: Introduction

675
Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
675
Pneumothorax-I01:26

Pneumothorax-I

1.1K
A pneumothorax is a condition where air builds up in the space between the lung and the chest wall, causing the lung to collapse. This condition arises when air enters the space between the parietal and visceral pleura, disrupting the negative pressure essential for lung inflation. This can lead to a partial or complete collapse of the lung.
Pneumothorax can be even further classified as spontaneous, traumatic, and tension pneumothorax.
1.1K
Pneumothorax-II01:27

Pneumothorax-II

807
Pneumothorax is a medical condition defined by the buildup of air in the pleural space between the lungs and the chest wall. This accumulation of air can lead to partial or complete lung collapse, resulting in a range of clinical manifestations. Understanding the clinical presentation and effective management strategies is crucial for healthcare professionals in providing timely and appropriate care to individuals with pneumothorax.
Clinical Manifestations:
807
Other Pulmonary Disorders01:17

Other Pulmonary Disorders

1.4K
Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
1.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Heterogeneity and clinical relevance of group 2 innate lymphoid cells subsets in nasal polyps.

The Journal of allergy and clinical immunology·2026
Same author

The Association Between Sinus Surgery and the Development of Asthma and Non-Cystic Fibrosis Bronchiectasis in Patients With Chronic Rhinosinusitis.

International forum of allergy & rhinology·2025
Same author

Effects of type 3 and neutrophilic inflammation on type 2 chronic rhinosinusitis with nasal polyps.

The Journal of allergy and clinical immunology·2025
Same author

Tezepelumab inhibits highly functional truncated thymic stromal lymphopoietin in chronic rhinosinusitis.

The Journal of allergy and clinical immunology·2025
Same author

Analysis of human neutrophils from nasal polyps by single-cell RNA sequencing reveals roles of neutrophils in chronic rhinosinusitis.

The Journal of allergy and clinical immunology·2024
Same author

Associations Between Chronic Rhinosinusitis and the Development of Non-Cystic Fibrosis Bronchiectasis.

The journal of allergy and clinical immunology. In practice·2024
Same journal

Key factors in the diagnosis of sesame allergy in children.

Allergy and asthma proceedings·2026
Same journal

Immunoglobulin E-mediated pumpkin seed allergy in children: Case series and narrative review with a structured literature search.

Allergy and asthma proceedings·2026
Same journal

Predictors of delayed treatment-free remission with omalizumab in chronic spontaneous urticaria.

Allergy and asthma proceedings·2026
Same journal

The digital front door: A national analysis of U.S. allergy and immunology fellowship program web sites.

Allergy and asthma proceedings·2026
Same journal

The impact of dietary patterns on the risk of asthma in children.

Allergy and asthma proceedings·2026
Same journal

The alpha-gal syndrome: Understanding the role of tick bites, and the delays in severe anaphylaxis.

Allergy and asthma proceedings·2026
See all related articles

Related Experiment Video

Updated: Jan 4, 2026

Pseudomonas aeruginosa Induced Lung Injury Model
07:24

Pseudomonas aeruginosa Induced Lung Injury Model

Published on: October 29, 2014

18.9K

Hypersensitivity pneumonitis.

Melissa M Watts, Leslie C Grammer

    Allergy and Asthma Proceedings
    |November 7, 2019
    PubMed
    Summary
    This summary is machine-generated.

    Hypersensitivity pneumonitis (HP), an allergic lung inflammation, is diagnosed using six key predictors. Early identification and understanding of triggers are crucial for managing this condition.

    More Related Videos

    Assessment of the Cytotoxic and Immunomodulatory Effects of Substances in Human Precision-cut Lung Slices
    12:04

    Assessment of the Cytotoxic and Immunomodulatory Effects of Substances in Human Precision-cut Lung Slices

    Published on: May 9, 2018

    14.6K
    The Utilization of Oropharyngeal Intratracheal PAMP Administration and Bronchoalveolar Lavage to Evaluate the Host Immune Response in Mice
    12:27

    The Utilization of Oropharyngeal Intratracheal PAMP Administration and Bronchoalveolar Lavage to Evaluate the Host Immune Response in Mice

    Published on: April 2, 2014

    17.2K

    Related Experiment Videos

    Last Updated: Jan 4, 2026

    Pseudomonas aeruginosa Induced Lung Injury Model
    07:24

    Pseudomonas aeruginosa Induced Lung Injury Model

    Published on: October 29, 2014

    18.9K
    Assessment of the Cytotoxic and Immunomodulatory Effects of Substances in Human Precision-cut Lung Slices
    12:04

    Assessment of the Cytotoxic and Immunomodulatory Effects of Substances in Human Precision-cut Lung Slices

    Published on: May 9, 2018

    14.6K
    The Utilization of Oropharyngeal Intratracheal PAMP Administration and Bronchoalveolar Lavage to Evaluate the Host Immune Response in Mice
    12:27

    The Utilization of Oropharyngeal Intratracheal PAMP Administration and Bronchoalveolar Lavage to Evaluate the Host Immune Response in Mice

    Published on: April 2, 2014

    17.2K

    Area of Science:

    • Pulmonary Medicine
    • Immunology
    • Allergy

    Background:

    • Hypersensitivity pneumonitis (HP), or extrinsic allergic alveolitis, is non-IgE mediated lung inflammation caused by inhaled antigens.
    • Etiologic agents include organic compounds (bacteria, fungi, proteins) and inorganic haptens (isocyanates, drugs).

    Purpose of the Study:

    • To outline the diagnostic criteria and clinical presentation of hypersensitivity pneumonitis.
    • To describe the immunologic mechanisms and staging of HP.

    Main Methods:

    • Identification of six significant predictors for HP diagnosis.
    • Clinical and radiographic findings in acute and chronic HP stages.
    • Analysis of immunologic markers in bronchoalveolar lavage fluid.

    Main Results:

    • Six predictors achieve ~95% diagnostic accuracy for HP.
    • Acute HP mimics influenza with fever, cough, dyspnea; chest X-ray shows nodular infiltrates.
    • Chronic HP presents with weight loss; immunologic response involves activated macrophages and CD8+ T cells.

    Conclusions:

    • HP diagnosis relies on a combination of exposure history, clinical symptoms, and diagnostic tests.
    • Understanding the immunologic response aids in comprehending HP pathogenesis.
    • Staging HP into acute, subacute, and chronic forms guides clinical management.