Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

31.9K
Overview
31.9K
Hypersensitivities01:30

Hypersensitivities

6.8K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
6.8K
Allergic Drug Reactions01:27

Allergic Drug Reactions

1.3K
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.3K
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

1.7K
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
1.7K
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

4.0K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
4.0K
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

5.1K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
5.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An International, Retrospective Study of Off-Label Biologic Use in the Treatment of Hypereosinophilic Syndromes.

The journal of allergy and clinical immunology. In practice·2022
Same author

Allergy/Immunology Trainee Experiences During the COVID-19 Pandemic: AAAAI Work Group Report of the Fellows-in-Training Committee.

The journal of allergy and clinical immunology. In practice·2020
Same author

Skin testing in allergy.

Allergy and asthma proceedings·2019
Same author

Allergen immunotherapy: definition, indications, and reactions.

Allergy and asthma proceedings·2019
Same author

Classification of asthma.

Allergy and asthma proceedings·2019
Same author

Acute severe asthma (status asthmaticus).

Allergy and asthma proceedings·2019
Same journal

Key factors in the diagnosis of sesame allergy in children.

Allergy and asthma proceedings·2026
Same journal

Immunoglobulin E-mediated pumpkin seed allergy in children: Case series and narrative review with a structured literature search.

Allergy and asthma proceedings·2026
Same journal

Predictors of delayed treatment-free remission with omalizumab in chronic spontaneous urticaria.

Allergy and asthma proceedings·2026
Same journal

The digital front door: A national analysis of U.S. allergy and immunology fellowship program web sites.

Allergy and asthma proceedings·2026
Same journal

The impact of dietary patterns on the risk of asthma in children.

Allergy and asthma proceedings·2026
Same journal

The alpha-gal syndrome: Understanding the role of tick bites, and the delays in severe anaphylaxis.

Allergy and asthma proceedings·2026
See all related articles

Related Experiment Video

Updated: Jan 4, 2026

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

9.2K

Urticaria and angioedema.

Canting Guo, Carol Saltoun

    Allergy and Asthma Proceedings
    |November 7, 2019
    PubMed
    Summary
    This summary is machine-generated.

    Urticaria, or hives, affects many people and can be acute or chronic. Chronic hives may be linked to autoimmune conditions and treated with antihistamines.

    More Related Videos

    Measuring Local Anaphylaxis in Mice
    07:49

    Measuring Local Anaphylaxis in Mice

    Published on: October 14, 2014

    19.9K
    Granulocyte-dependent Autoantibody-induced Skin Blistering
    12:23

    Granulocyte-dependent Autoantibody-induced Skin Blistering

    Published on: October 12, 2012

    10.8K

    Related Experiment Videos

    Last Updated: Jan 4, 2026

    Basophil Activation Test for Allergy Diagnosis
    07:22

    Basophil Activation Test for Allergy Diagnosis

    Published on: May 31, 2021

    9.2K
    Measuring Local Anaphylaxis in Mice
    07:49

    Measuring Local Anaphylaxis in Mice

    Published on: October 14, 2014

    19.9K
    Granulocyte-dependent Autoantibody-induced Skin Blistering
    12:23

    Granulocyte-dependent Autoantibody-induced Skin Blistering

    Published on: October 12, 2012

    10.8K

    Area of Science:

    • Immunology
    • Dermatology

    Background:

    • Urticaria (hives) affects up to 20% of the population.
    • Characterized by itchy, raised lesions, often with angioedema.
    • Classified as acute (<6 weeks) or chronic (>6 weeks).

    Purpose of the Study:

    • To review the characteristics and potential autoimmune basis of chronic urticaria.
    • To discuss diagnostic considerations and treatment approaches.

    Main Methods:

    • Literature review of urticaria and angioedema.
    • Discussion of diagnostic markers for autoimmune urticaria.
    • Overview of treatment strategies.

    Main Results:

    • Chronic urticaria often lacks identifiable causes and may have autoimmune links.
    • Associations found with autoimmune hypothyroidism (Hashimoto disease).
    • Circulating IgG antibodies against FcεRI or IgE present in 40-60% of chronic urticaria patients.

    Conclusions:

    • Chronic urticaria may have an autoimmune etiology.
    • Identifying autoimmune markers like antithyroid antibodies or anti-FcεRI/IgE antibodies is important.
    • Second-generation H1 antihistamines are the recommended first-line therapy.