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Amiodarone therapy and glucose tolerance--a prospective trial
A A Lakhdar1, E Farish, F G Dunn
1Department of Endocrinology, Stobhill General Hospital, Glasgow, U.K.
European Journal of Clinical Pharmacology
|January 1, 1988
Summary
This study found no evidence that amiodarone therapy causes glucose intolerance or diabetes in patients with cardiac arrhythmias. Prolonged amiodarone use did not negatively impact glucose metabolism.
Area of Science:
- Cardiology
- Endocrinology
- Pharmacology
Background:
- Amiodarone is a widely used antiarrhythmic drug.
- Previous research suggested amiodarone may induce glucose intolerance.
Purpose of the Study:
- To prospectively investigate the potential diabetogenic effect of amiodarone in patients with normal glucose tolerance.
Main Methods:
- A prospective study of 10 patients receiving amiodarone for arrhythmias.
- Glucose tolerance tests and glycosylated hemoglobin measured every 3 months for 9 months.
Main Results:
- Fasting blood glucose and glucose tolerance tests remained within normal limits throughout the study.
- Glycosylated hemoglobin showed a transient, non-pathological rise at 6 months, not sustained at 9 months.
Conclusions:
- Prolonged amiodarone therapy in patients with normal glucose tolerance did not lead to glucose intolerance.
- No evidence of a diabetogenic effect was observed during this study.