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Elevated Hs-CRP Levels Are Associated with Higher Risk of Intracranial Arterial Stenosis

Bing-Jie Su1, Yi Dong2, Chen-Chen Tan1

  • 1Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, 266071, China.

Neurotoxicity Research
|November 7, 2019
PubMed

Insights

Elevated high-sensitivity C-reactive protein (hs-CRP) levels are linked to a higher risk of intracranial arterial stenosis (ICAS). This association was observed in both stroke patients and individuals without a stroke history.

Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Biomarkers

Background:

  • The relationship between high-sensitivity C-reactive protein (hs-CRP) and intracranial arterial stenosis (ICAS) requires further clarification.
  • Inflammation plays a role in atherosclerosis and cerebrovascular diseases.

Purpose of the Study:

  • To investigate the association between serum hs-CRP levels and the presence of ICAS.
  • To determine if hs-CRP is a risk factor for ICAS in a population aged 40 years and older.

Main Methods:

  • A cohort of 1458 participants aged ≥40 years underwent magnetic resonance angiography (MRA) to assess for ICAS.
  • Participants were categorized based on stroke status and ICAS presence.
  • Multivariable logistic regression models were employed to analyze the relationship between hs-CRP levels and ICAS.

Main Results:

  • Intracranial arterial stenosis (ICAS) was identified in 432 (29.63%) participants.
  • Patients in the stroke group exhibited significantly higher hs-CRP levels compared to the non-stroke group (p < 0.001).
  • Higher hs-CRP levels were significantly associated with the presence of ICAS (p < 0.001). The highest quartile of hs-CRP showed the strongest association with ICAS in both stroke and non-stroke groups (OR 2.512 and 2.534, respectively).

Conclusions:

  • Elevated serum hs-CRP levels are independently associated with an increased risk of intracranial arterial stenosis (ICAS).
  • hs-CRP may serve as a valuable biomarker for identifying individuals at risk for ICAS, irrespective of stroke history.

Keywords:
AtherosclerosisHigh-sensitivity C-reactive proteinInflammationIntracranial arterial stenosisStroke

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