Related Experiment Video

Updated: Jan 4, 2026

Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells
06:47

Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells

Published on: May 4, 2018

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Retracted: Inhibition of miR-23a-3p promotes osteoblast proliferation and differentiation

    Journal of Cellular Biochemistry
    |November 7, 2019
    PubMed

    Insights

    This study on miR-23a-3p and osteoblast function has been retracted due to significant flaws. The journal editors invalidated the findings after discovering inconsistencies in the research methods and results.

    Area of Science:

    • Biochemistry
    • Molecular Biology
    • Cell Biology

    Background:

    • MicroRNAs (miRNAs) play crucial roles in cellular processes.
    • miR-23a-3p has been implicated in bone metabolism.
    • Understanding miRNA regulation is vital for bone biology research.

    Purpose of the Study:

    • To investigate the role of miR-23a-3p in osteoblast proliferation and differentiation.
    • To explore the potential of targeting miR-23a-3p for bone regeneration.

    Main Methods:

    • The study utilized molecular biology techniques to analyze miR-23a-3p expression.
    • Osteoblast cell cultures were employed to assess proliferation and differentiation markers.
    • Experimental methods included gene expression analysis and functional assays.

    Main Results:

    • The original article claimed that inhibiting miR-23a-3p promoted osteoblast proliferation and differentiation.
    • Specific molecular pathways were suggested to be involved in this process.

    Conclusions:

    • The conclusions of the original study are considered invalid due to identified flaws.
    • The retraction highlights the importance of rigorous methodology and data integrity in scientific publishing.

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