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Isatin-azole hybrids and their anticancer activities
Yani Hou1, Congshan Shang1, Hui Wang1
1School of Medicine, Xi'an Peihua University, Xi'an, China.
Archiv Der Pharmazie
|November 7, 2019
Summary
Hybridizing isatin and azole compounds creates novel anticancer agents. This review highlights promising isatin-azole hybrids developed between 2010-2019, discussing their structure-activity relationships and mechanisms for cancer treatment.
Area of Science:
- Medicinal Chemistry
- Drug Discovery
- Oncology
Background:
- Isatin and azole are key pharmacophores in drug development due to their interaction capabilities.
- Isatin and azole derivatives demonstrate significant in vitro and in vivo anticancer potential.
- Existing drugs like semaxanib and sunitinib showcase the therapeutic value of these moieties.
Purpose of the Study:
- To review the development of isatin-azole hybrids as anticancer agents.
- To analyze structure-activity relationships (SAR) of these hybrids.
- To discuss their mechanisms of action for improved drug design.
Main Methods:
- Literature review of articles published between 2010 and 2019.
- Analysis of structural modifications and their impact on anticancer activity.
- Examination of reported mechanisms of action.
Main Results:
- Several isatin-azole hybrids exhibit considerable anticancer activity.
- Specific structural features correlate with enhanced efficacy.
- Diverse mechanisms of action have been identified.
Conclusions:
- Isatin-azole hybrids represent a promising strategy for novel cancer therapeutics.
- Understanding SAR and mechanisms is crucial for rational drug design.
- Further research into these hybrids could lead to more effective cancer treatments.
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