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Long non-coding small nucleolar RNA host genes in digestive cancers
Huan Yang1, Zheng Jiang2, Shuang Wang2,3
1Department of Gastroenterology, Xinqiao Hospital, Army Medical University, Chongqing, China.
Cancer Medicine
|November 7, 2019
Summary
Long non-coding RNA host genes (lnc-SNHGs) are crucial in digestive cancer development. This review details their roles in tumor formation and progression, highlighting their impact on cell behavior.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Long noncoding RNAs (lncRNAs) are key regulators in cancer pathogenesis.
- Long non-coding small nucleolar RNA host genes (lnc-SNHGs) show abnormal expression across various cancers.
- lnc-SNHGs are implicated in tumorigenesis, affecting cell proliferation, migration, invasion, and apoptosis.
Purpose of the Study:
- To provide an overview of the roles of lnc-SNHGs in digestive cancers.
- To summarize the involvement of lnc-SNHGs in the formation and progression of digestive tumors.
Main Methods:
- Literature review of studies on lnc-SNHGs and digestive cancers.
- Analysis of existing research on the molecular mechanisms of lnc-SNHGs in tumorigenesis.
Main Results:
- lnc-SNHGs are frequently dysregulated in digestive cancers.
- These lncRNAs influence critical cancer hallmarks, including proliferation, migration, invasion, and apoptosis.
- lnc-SNHGs represent potential therapeutic targets in digestive cancer treatment.
Conclusions:
- lnc-SNHGs play significant roles in the development and progression of digestive cancers.
- Understanding lnc-SNHG functions is vital for advancing digestive cancer research and therapy.
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