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Long non-coding small nucleolar RNA host genes in digestive cancers

Huan Yang1, Zheng Jiang2, Shuang Wang2,3

  • 1Department of Gastroenterology, Xinqiao Hospital, Army Medical University, Chongqing, China.

Cancer Medicine
|November 7, 2019
PubMed

Insights

Long non-coding RNA host genes (lnc-SNHGs) are crucial in digestive cancer development. This review details their roles in tumor formation and progression, highlighting their impact on cell behavior.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Long noncoding RNAs (lncRNAs) are key regulators in cancer pathogenesis.
  • Long non-coding small nucleolar RNA host genes (lnc-SNHGs) show abnormal expression across various cancers.
  • lnc-SNHGs are implicated in tumorigenesis, affecting cell proliferation, migration, invasion, and apoptosis.

Purpose of the Study:

  • To provide an overview of the roles of lnc-SNHGs in digestive cancers.
  • To summarize the involvement of lnc-SNHGs in the formation and progression of digestive tumors.

Main Methods:

  • Literature review of studies on lnc-SNHGs and digestive cancers.
  • Analysis of existing research on the molecular mechanisms of lnc-SNHGs in tumorigenesis.

Main Results:

  • lnc-SNHGs are frequently dysregulated in digestive cancers.
  • These lncRNAs influence critical cancer hallmarks, including proliferation, migration, invasion, and apoptosis.
  • lnc-SNHGs represent potential therapeutic targets in digestive cancer treatment.

Conclusions:

  • lnc-SNHGs play significant roles in the development and progression of digestive cancers.
  • Understanding lnc-SNHG functions is vital for advancing digestive cancer research and therapy.
Keywords:
LncRNASNHGcancerdigestive

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