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Updated: Jan 4, 2026

Setting a Successful Sorting for Extracellular Vesicle Isolation
Published on: October 11, 2024
Regeneration-Related Functional Cargoes in Mesenchymal Stem Cell-Derived Small Extracellular Vesicles
Zhongyi Zhu1,2, Yijing Zhang1,2,3, Ligang Wu4,5
1Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
Abstract:
Mesenchymal stem cell-derived small extracellular vesicles (MSC-sEV) are the primary effective source in stem cell-dependent regenerative medicine due to their preponderances over direct MSC implantation. An increasing number of studies have been carried out on MSC-sEV derived from different types of cells, and their function of accelerating tissue repair was proved. However, only a few researches were able to demonstrate the functional cargoes in MSC-sEV or their mechanisms in promoting tissue recovery. In this review, we present current achievements in discovering MSC-sEV-carried RNAs and proteins as promoters in tissue regeneration. Their therapeutic function includes modulating immune reactivity, promoting angiogenesis, and accelerating cell proliferation and migration through orchestrates of cell signaling pathways.
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