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Association Between Personality Traits and Onabotulinumtoxin A Response in Patients With Chronic Migraine

Alicia Gonzalez-Martinez1, Eva Rodríguez Vázquez2, Henar de la Red Gallego2

  • 1Headache Unit, Neurology Department, Hospital Universitario de La Princesa & Instituto de Investigación Sanitaria de La Princesa, Madrid, Spain.

Headache
|November 7, 2019
PubMed
Abstract

Insights

This study found that a dependent personality trait is linked to a poorer response to onabotulinumtoxin A (onabotA) treatment in chronic migraine patients. Understanding personality traits may help predict treatment outcomes for onabotA in migraine management.

Area of Science:

  • Neurology
  • Psychiatry
  • Clinical Medicine

Background:

  • Chronic migraine (CM) patients may exhibit anxious or obsessive personality traits.
  • Previous research has not explored the impact of personality on onabotulinumtoxin A (onabotA) efficacy in CM.
  • This study hypothesizes a link between Cluster C personality traits and non-response to onabotA.

Purpose of the Study:

  • To investigate the association between personality traits and treatment response to onabotulinumtoxin A (onabotA) in patients suffering from chronic migraine (CM).

Main Methods:

  • A case-control observational study involving 112 CM patients who underwent at least two onabotA treatment cycles.
  • OnabotA response was defined as a ≥50% reduction in monthly migraine days.
  • Personality traits were assessed using the validated Salamanca questionnaire.

Main Results:

  • 85.7% of patients (96/112) responded to onabotA treatment.
  • A dependent personality trait was significantly associated with non-response to onabotA (P=.008; OR: 0.223).
  • No significant associations were found between other personality traits or confounders and onabotA response.

Conclusions:

  • This is the first study to suggest that personality traits can predict onabotA response in chronic migraine patients.
  • The presence of a dependent personality trait in CM patients is linked to a lower likelihood of responding to onabotA treatment.
Keywords:
Salamanca questionnairechronic migrainedependent traitonabotApersonality trait

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