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Updated: Jan 4, 2026
HPLC-based Assay to Monitor Extracellular Nucleotide/Nucleoside Metabolism in Human Chronic Lymphocytic Leukemia Cells
Published on: July 20, 2016
Positive predictive value of CD200 positivity in the differential diagnosis of chronic lymphocytic leukemia
Marc Sorigue1, Laura Magnano2, Milos D Miljkovic3
1Hematology Laboratory, ICO-Hospital Germans Trias i Pujol. IJC, Universitat Autònoma de Barcelona, Badalona, Spain.
Background:
The role of CD200 in the differential diagnosis of chronic lymphocytic leukemia (CLL) and classical mantle cell lymphoma (MCL) is well established. Its role in the differential diagnosis of CLL and other lymphoproliferative disorders (LPD) is less clear, in particular its positive predictive value (PPV).
Materials And Methods:
We conducted a systematic review of the use of CD200 in the differential diagnosis of CLL, MCL, and other predominantly leukemic, typically CD103-negative LPD. With the results, we then derived a curve to determine the PPV based on the prevalence of the disorders included in the differential diagnosis.
Results:
Of 43 publications screened, 27 were included in the systematic review (5,764 patients). The median CD200 positivity rate in all studies and the percentage of CD200-positive (pooled) patients was 100% and 95% (3,061/3,208) in CLL, 4 and 8% (86/1112) in MCL and 56 and 62% (425/689) in other LPD.
Conclusion:
CD200 is suboptimal for the differential diagnosis of CLL and disorders other than nodal MCL.
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