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Associations Between microRNA Polymorphisms and Development of Coronary Artery Disease: A Case-Control Study

Hao Qiu1, Zheng Chen2, Lu Lv3

  • 1Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang, China.

DNA and Cell Biology
|November 7, 2019
PubMed

Insights

Genetic variations in microRNA-196a2 (miR-196a2) rs11614913 may reduce the risk of coronary artery disease (CAD) and myocardial infarction (MI), particularly in women. Further research is needed to confirm these findings.

Area of Science:

  • Genetics
  • Cardiovascular Medicine
  • Molecular Biology

Background:

  • Coronary artery disease (CAD) is a leading global cause of mortality.
  • Genetic polymorphisms in microRNAs (miRNAs) are potential contributors to CAD susceptibility.
  • Specific miRNA single nucleotide polymorphisms (SNPs) warrant investigation for their role in CAD.

Purpose of the Study:

  • To investigate the association between selected miRNA SNPs (miR-146a, miR-196a2, miR-499) and CAD risk.
  • To analyze the impact of miR-196a2 rs11614913 polymorphism on myocardial infarction (MI) and CAD susceptibility.
  • To explore potential gender-specific effects of miR-196a2 rs11614913 on CAD risk.

Main Methods:

  • A case-control study involving 505 CAD cases and 1109 controls.
  • Genotyping of miR-146a rs2910164, miR-196a2 rs11614913, and miR-499 rs3746444 variants using the SNPscan™ assay.
  • Statistical analysis to determine adjusted p-values for genotype comparisons.

Main Results:

  • The miR-196a2 rs11614913 T>C polymorphism was associated with decreased susceptibility to MI (adjusted p=0.007 for TC vs. TT; p=0.012 for CC/TC vs. TT).
  • In the female subgroup, miR-196a2 rs11614913 T>C variants showed a trend towards decreased CAD susceptibility (adjusted p=0.017 for TC vs. TT; p=0.015 for TC/CC vs. TT).

Conclusions:

  • The miR-196a2 rs11614913 T>C locus may decrease susceptibility to CAD in females and MI.
  • These findings suggest a potential protective role of specific miR-196a2 genotypes against cardiovascular disease.
  • Further validation studies are recommended to confirm the association between miR-196a2 rs11614913 and CAD.

Keywords:
coronary artery diseasemicroRNApolymorphismrisk

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