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Attachment of Sister Chromatids02:57

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As cells progress into mitosis, the nuclear envelope breaks down, and the condensed chromosomes are exposed to the array of bipolar microtubules of the mitotic spindle. The kinetochore, a large, disc-shaped protein complex, is present at the centromere region of the sister chromatids and acts as a binding site for the microtubules.  Usually, the plus-end of a single microtubule is embedded within the kinetochore. However, some kinetochores first establish lateral contact with the side-wall...
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The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
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Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
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The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
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The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
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Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
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<b>Erratum: JEAN-PAUL HAENNI & KAWTAR KETTANI (2026) The Bibionidae (Diptera) from Morocco, with description of four new species. <i>Zootaxa</i>, 5793 (2): 392-420.</b>

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Related Experiment Video

Updated: Jan 4, 2026

Use of Electromagnetic Navigational Transthoracic Needle Aspiration E-TTNA for Sampling of Lung Nodules
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[Sister Mary Joseph nodule].

Kawtar Kettani1, Imane Chahid2

  • 1Département Pédiatrie 3 CHU Ibn Rochd, Casablanca, Maroc.

The Pan African Medical Journal
|November 7, 2019
PubMed
Summary

A rare Sister Mary Joseph nodule, an umbilical metastasis, indicated Burkitt lymphoma in a pediatric patient. Prompt chemotherapy led to favorable outcomes, with regression of the nodule and abdominal masses.

Area of Science:

  • Oncology
  • Pathology

Context:

  • Sister Mary Joseph nodule is a rare clinical sign of advanced abdominopelvic malignancy.
  • Typically associated with adenocarcinoma, it can exceptionally indicate lymphoma.

Purpose:

  • To report a rare case of Burkitt lymphoma presenting as a Sister Mary Joseph nodule in a pediatric patient.
  • To highlight the importance of recognizing this sign for timely diagnosis and management of underlying neoplasms.

Summary:

  • A 6-year-old female presented with abdominal pain, distension, and an umbilical mass later diagnosed as Burkitt lymphoma.
  • Imaging revealed extensive intra-abdominal disease, including mesenteric lymphadenopathy and pelvic mass.
  • Fine needle aspiration confirmed lymphoma, and chemotherapy via the LMB01 protocol resulted in a positive outcome.
Keywords:
Lymphomanoduleumbilicus

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Impact:

  • This case underscores that a Sister Mary Joseph nodule can be a sign of lymphoma, not just adenocarcinoma.
  • Early recognition and diagnosis are crucial for improving prognosis in patients with this rare metastatic sign.