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In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice
Published on: August 23, 2019
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circ_0005273 promotes thyroid carcinoma progression by SOX2 expression.
Wei Zhang1, Hang Zhang2, Xudong Zhao2
1Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang City, Liaoning Province, China.
Endocrine-Related Cancer
|November 7, 2019
Summary
Circular RNAs (circRNAs) like circ_0005273 promote papillary thyroid carcinoma (PTC) progression. Targeting the circ_0005273/miR-1183/SOX2 pathway may offer new therapeutic strategies for PTC.
Area of Science:
- Endocrinology
- Oncology
- Molecular Biology
Background:
- Papillary thyroid carcinoma (PTC) is a common endocrine tumor.
- Circular RNAs (circRNAs) play a significant role in PTC development.
- Understanding specific circRNAs, like circ_0005273, is crucial for PTC research.
Purpose of the Study:
- To investigate the function and molecular mechanism of circ_0005273 in papillary thyroid carcinoma (PTC).
- To explore circ_0005273 as a potential biomarker and therapeutic target for PTC.
Main Methods:
- Analysis of Gene Expression Omnibus datasets (GSE93522) and quantitative real-time PCR (qRT-PCR).
- In vivo and in vitro functional assays (e.g., Cell Counting Kit-8, colony formation, transwell assays).
- Investigation of the interaction between circ_0005273, miR-1183, and SOX2.
Main Results:
- Circ_0005273 was found to be upregulated in PTC tissues and cell lines.
- Knockdown of circ_0005273 inhibited PTC tumor growth and progression.
- Circ_0005273 promotes PTC by regulating the miR-1183/SOX2 axis.
Conclusions:
- Circ_0005273 acts as an oncogenic factor in papillary thyroid carcinoma.
- The circ_0005273/miR-1183/SOX2 axis is a key pathway in PTC progression.
- Circ_0005273 represents a potential diagnostic biomarker and therapeutic target for PTC.
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