Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gradient and Del Operator01:14

Gradient and Del Operator

4.3K
In mathematics and physics, the gradient and del operator are fundamental concepts used to describe the behavior of functions and fields in space. The gradient is a mathematical operator that gives both the magnitude and direction of the maximum spatial rate of change. Consider a person standing on a mountain. The slope of the mountain at any given point is not defined unless it is quantified in a particular direction. For this reason, a "directional derivative" is defined, which is a vector...
4.3K
What is an Electrochemical Gradient?01:26

What is an Electrochemical Gradient?

126.3K
Adenosine triphosphate, or ATP, is considered the primary energy source in cells. However, energy can also be stored in the electrochemical gradient of an ion across the plasma membrane, which is determined by two factors: its chemical and electrical gradients.
The chemical gradient relies on differences in the abundance of a substance on the outside versus the inside of a cell and flows from areas of high to low ion concentration. In contrast, the electrical gradient revolves around an...
126.3K
Design Example: Aggregate Gradation01:24

Design Example: Aggregate Gradation

278
The right type and quality of aggregates are crucial for concrete as they significantly influence its properties, mix proportions, and cost-effectiveness. If different sources are available for sand, the commonly used fine aggregate in concrete, the selection of sand is primarily based on its gradation.
The grading, or particle-size distribution, of sand is determined using sieve analysis, with standard sizes ranging from 150 μm to 10 mm (ASTM No. 100 sieve to 3⁄8 in. sieve). Sand is...
278
Graded Potential01:19

Graded Potential

6.6K
Graded potentials are localized fluctuations in the cell membrane's electrical charge, commonly found in the dendrites of neurons. The magnitude of these potential changes depends on the strength of the initiating stimulus. In a membrane at its resting potential, a graded potential signifies a voltage shift either above -70 mV or below -70 mV.
Graded potentials fall into two categories: depolarizing and hyperpolarizing. Depolarizing graded potentials typically occur when sodium (Na+) or...
6.6K
Energy Line and Hydraulic Gradient Line01:27

Energy Line and Hydraulic Gradient Line

2.0K
Based on Bernoulli's equation, the energy line (EL) and hydraulic grade line (HGL) provide graphical representations of energy distribution in a fluid flow system. For steady, incompressible, inviscid flows, Bernoulli's equation is expressed as:
2.0K
Electrochemical Gradient and Channel Proteins: An Overview01:21

Electrochemical Gradient and Channel Proteins: An Overview

4.2K
An electrochemical gradient is a fundamental concept in biology and chemistry. It regulates the movement of ions across cell membranes. This movement is influenced by two factors:
The electrical gradient: The electrical gradient across cell membranes refers to the difference in electric charge between the inside and outside of a cell.  This difference drives the movement of ions towards or away from the cells. For instance, if the inside of the cell is more negatively charged relative to...
4.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Editorial: Repurposing for small population needs.

Frontiers in medicine·2026
Same author

Repurposing Empagliflozin for Duchenne Muscular Dystrophy-Associated Cardiomyopathy: Protocol for a Pharmacokinetics, Safety and Proof-of-Concept Trial in Children.

Cardiology and therapy·2026
Same author

Time to accelerate rare disease research: AI-powered in silico trials, digital twin-driven RCTs and decision-grade real-world evidence.

British journal of clinical pharmacology·2026
Same author

Empagliflozin in paediatric heart failure: model-based optimisation of a pharmacokinetic bridging study.

Frontiers in medicine·2026
Same author

Use of lorazepam for analgosedation during mechanical ventilation in pediatric intensive care.

Frontiers in medicine·2026
Same author

An open-label, single-arm, dose-escalating concentration-QT study to investigate the cardiac effects and safety of paroxetine in healthy adults.

British journal of clinical pharmacology·2026

Related Experiment Video

Updated: Jan 4, 2026

A Gradient-generating Microfluidic Device for Cell Biology
11:05

A Gradient-generating Microfluidic Device for Cell Biology

Published on: August 30, 2007

15.8K

Introducing Project Africa GRADIENT

Iris Rajman1, Oscar Della Pasqua2, 2

  • 1Translational Medicine Asia, Novartis Institutes for Biomedical Research, Novartis NKK, Tokyo, Japan.

Drug Discovery Today
|November 7, 2019
PubMed
Summary

No abstract available in PubMed .

More Related Videos

Fabrication of Gradient Nanopattern by Thermal Nanoimprinting Technique and Screening of the Response of Human Endothelial Colony-forming Cells
11:24

Fabrication of Gradient Nanopattern by Thermal Nanoimprinting Technique and Screening of the Response of Human Endothelial Colony-forming Cells

Published on: July 1, 2018

8.3K
Planar Gradient Diffusion System to Investigate Chemotaxis in a 3D Collagen Matrix
09:26

Planar Gradient Diffusion System to Investigate Chemotaxis in a 3D Collagen Matrix

Published on: June 12, 2015

8.9K

Related Experiment Videos

Last Updated: Jan 4, 2026

A Gradient-generating Microfluidic Device for Cell Biology
11:05

A Gradient-generating Microfluidic Device for Cell Biology

Published on: August 30, 2007

15.8K
Fabrication of Gradient Nanopattern by Thermal Nanoimprinting Technique and Screening of the Response of Human Endothelial Colony-forming Cells
11:24

Fabrication of Gradient Nanopattern by Thermal Nanoimprinting Technique and Screening of the Response of Human Endothelial Colony-forming Cells

Published on: July 1, 2018

8.3K
Planar Gradient Diffusion System to Investigate Chemotaxis in a 3D Collagen Matrix
09:26

Planar Gradient Diffusion System to Investigate Chemotaxis in a 3D Collagen Matrix

Published on: June 12, 2015

8.9K